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Literature summary extracted from

  • Ishiguro, K.; Green, T.; Rapley, J.; Wachtel, H.; Giallourakis, C.; Landry, A.; Cao, Z.; Lu, N.; Takafumi, A.; Goto, H.; Daly, M.J.; Xavier, R.J.
    Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation (2006), Mol. Cell. Biol., 26, 5497-5508.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 expression in Jurkat cells, co-expression with human CARMA1, T-cell receptor engagement redistributes CaMKII to the immune synapse in an activation-dependent manner Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN93 binds to the calmodulin-binding site of CaMKII and inhibits its activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 additional information T-cell receptor engagement redistributes CaMKII to the immune synapse, which is interfered by inhibitor KN93, overview Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Homo sapiens
2.7.11.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + Blc10 Homo sapiens Bcl10 is essential for antigen receptor-induced NF-kappaB activation, interleukin-2 production, and T-cell proliferation but is not required for TCR-induced tyrosine phosphorylation, calcium flux, or extracellular signal-regulated kinase activation ADP + phosphorylated Blc10
-
 ?
2.7.11.17 ATP + CARMA1 Homo sapiens CaMKII is a modulator of CARMA1-mediated NF-kappaB activation, overview ADP + phosphorylated CARMA1
-
 ?
2.7.11.17 additional information Homo sapiens CaMKII substrates CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens
-
 isozymes CaMKIIgamma and CaMKIIdelta
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 lymphocyte
-
 Homo sapiens
-
2.7.11.17 neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + Blc10 activation Homo sapiens ADP + phosphorylated Blc10
-
 ?
2.7.11.17 ATP + Blc10 Bcl10 is essential for antigen receptor-induced NF-kappaB activation, interleukin-2 production, and T-cell proliferation but is not required for TCR-induced tyrosine phosphorylation, calcium flux, or extracellular signal-regulated kinase activation Homo sapiens ADP + phosphorylated Blc10
-
 ?
2.7.11.17 ATP + CARMA1 CaMKII is a modulator of CARMA1-mediated NF-kappaB activation, overview Homo sapiens ADP + phosphorylated CARMA1
-
 ?
2.7.11.17 ATP + CARMA1 activation by phosphorylation at Ser109, interaction with Bcl10 is facilitated Homo sapiens ADP + phosphorylated CARMA1
-
 ?
2.7.11.17 additional information CaMKII substrates CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Homo sapiens
2.7.11.17 CaMKII
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.17 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.17 7.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Homo sapiens