EC Number | Application | Comment | Organism |
---|---|---|---|
1.8.1.9 | medicine | development of novel anticancer agents | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.9 | palmarumycin CP1 | 0.001 mM, the naphthoquinone spiroketal fungal metabolite palmarumycin CP1 is a potent inhibitor of thioredoxin reductase-1, IC50: 0.00035 mM | Homo sapiens | |
1.8.1.9 | PX-911 | 0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, IC50: 0.0032 mM | Homo sapiens | |
1.8.1.9 | PX-916 | 0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, potent inhibitor of purified human thioredoxin reductase-1, IC50: 0.00028 mM | Homo sapiens | |
1.8.1.9 | PX-960 | 0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, IC50: 0.00027 mM | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.8.1.9 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.9 | selenium | 0.001 mM, 5fold increase of activity after 7 days | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.9 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.1.9 | breast cancer cell | - |
Homo sapiens | - |
1.8.1.9 | MCF-7 cell | - |
Homo sapiens | - |
1.8.1.9 | rhabdomyosarcoma cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | - |
Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.9 | NADPH-dependent thioredoxin reductase-1 | - |
Homo sapiens |
1.8.1.9 | thioredoxin reductase | - |
Homo sapiens |
1.8.1.9 | TrxR | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.8.1.9 | 0.00027 | - |
0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, IC50: 0.00027 mM | Homo sapiens | PX-960 | |
1.8.1.9 | 0.00028 | - |
0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, potent inhibitor of purified human thioredoxin reductase-1, IC50: 0.00028 mM | Homo sapiens | PX-916 | |
1.8.1.9 | 0.00035 | - |
0.001 mM, the naphthoquinone spiroketal fungal metabolite palmarumycin CP1 is a potent inhibitor of thioredoxin reductase-1, IC50: 0.00035 mM | Homo sapiens | palmarumycin CP1 | |
1.8.1.9 | 0.0032 | - |
0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, IC50: 0.0032 mM | Homo sapiens | PX-911 |