Literature summary extracted from

Wang, Y.; Zhen, Y.; Shi, Y.; Chen, J.; Zhang, C.; Wang, X.; Yang, X.; Zheng, Y.; Liu, Y.; Hui, R.
Vitamin K epoxide reductase: a protein involved in angiogenesis (2005), Mol. Cancer Res., 3, 317-323.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.17.4.4	additional information	enzyme overexpression stimulates cell proliferation, while inhibition of enzyme expression by antisense constructs reduces it, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.17.4.4	2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol	Homo sapiens	i.e. vitamin K 2,3-epoxide	2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol	i.e. vitamin K, an important cofactor for the posttranslational gamma-carboxylation of several blood coagulation factors	?
1.17.4.4	additional information	Homo sapiens	the enzyme is involved in angiogenesis	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.17.4.4	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.17.4.4	artery	mainly in vascular endothelium	Homo sapiens	-
1.17.4.4	fibroblast	dermal, low expression rate	Homo sapiens	-
1.17.4.4	heart	the enzyme is upregulated in fetal heart and in ventricular aneurysm tissue	Homo sapiens	-
1.17.4.4	HUVEC cell	-	Homo sapiens	-
1.17.4.4	additional information	quantitative expression analysis, no enzyme expression in peripheral blood leukocytes, the enzyme is upregulated in tumour tissue, overview	Homo sapiens	-
1.17.4.4	ventricular aneurysm tissue	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.17.4.4	2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol	i.e. vitamin K 2,3-epoxide	Homo sapiens	2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol	i.e. vitamin K	?
1.17.4.4	2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol	i.e. vitamin K 2,3-epoxide	Homo sapiens	2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol	i.e. vitamin K, an important cofactor for the posttranslational gamma-carboxylation of several blood coagulation factors	?
1.17.4.4	additional information	the enzyme is involved in angiogenesis	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.17.4.4	vitamin K epoxide reductase	-	Homo sapiens
1.17.4.4	VKOR	-	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.17.4.4	30	-	assay at	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
1.17.4.4	7.4	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)