EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.17.4.4 | additional information | enzyme overexpression stimulates cell proliferation, while inhibition of enzyme expression by antisense constructs reduces it, overview | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Homo sapiens | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K, an important cofactor for the posttranslational gamma-carboxylation of several blood coagulation factors | ? | |
1.17.4.4 | additional information | Homo sapiens | the enzyme is involved in angiogenesis | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.4.4 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.4.4 | artery | mainly in vascular endothelium | Homo sapiens | - |
1.17.4.4 | fibroblast | dermal, low expression rate | Homo sapiens | - |
1.17.4.4 | heart | the enzyme is upregulated in fetal heart and in ventricular aneurysm tissue | Homo sapiens | - |
1.17.4.4 | HUVEC cell | - |
Homo sapiens | - |
1.17.4.4 | additional information | quantitative expression analysis, no enzyme expression in peripheral blood leukocytes, the enzyme is upregulated in tumour tissue, overview | Homo sapiens | - |
1.17.4.4 | ventricular aneurysm tissue | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Homo sapiens | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Homo sapiens | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K, an important cofactor for the posttranslational gamma-carboxylation of several blood coagulation factors | ? | |
1.17.4.4 | additional information | the enzyme is involved in angiogenesis | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.4.4 | vitamin K epoxide reductase | - |
Homo sapiens |
1.17.4.4 | VKOR | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.17.4.4 | 30 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.17.4.4 | 7.4 | - |
assay at | Homo sapiens |