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Literature summary extracted from

  • Sirakova, T.D.; Dubey, V.S.; Deb, C.; Daniel, J.; Korotkova, T.A.; Abomoelak, B.; Kolattukudy, P.E.
    Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress (2006), Microbiology, 152, 2717-2725.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.20 additional information tgs transcript levels are upregulated under various stress culture conditions Mycobacterium tuberculosis

Application

EC Number Application Comment Organism
2.3.1.20 drug development the enzyme is a possible target for antilatency drugs Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.20 gene tgs1, expressionin Escherichia coli, the recombinant enzyme prefers C26 : 0-CoA for triglycerol accumulation Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.20 additional information disruption of gene tgs1, i.e. Rv3130c, leads to drastically reduced triacylglycerol accumulation Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.20 Mg2+
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.20 Mycobacterium tuberculosis
-
-
-
2.3.1.20 Mycobacterium tuberculosis
-
 strain ATCC 25618, gene tgs1 or Rv3130c
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.20 diolein + hexacosanoyl-CoA
-
 Mycobacterium tuberculosis ?
-
 ?
2.3.1.20 diolein + oleoyl-CoA
-
 Mycobacterium tuberculosis triolein + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.20 diacylglycerol acyltransferase
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.20 37
-
 assay at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.20 6.5
-
 assay at Mycobacterium tuberculosis