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Literature summary extracted from

  • Gardner-Stephen, D.A.; Gregory, P.A.; Mackenzie, P.I.
    Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes (2005), Methods Enzymol., 400, 22-46.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 2
-
 acetaminophen
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P19224
-
-
2.4.1.17 Rattus norvegicus P08430
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 brain
-
 Homo sapiens
-
2.4.1.17 brain mostly in the hippocampus and cerebellum Rattus norvegicus
-
2.4.1.17 Caco-2 cell
-
 Homo sapiens
-
2.4.1.17 colon
-
 Homo sapiens
-
2.4.1.17 colon
-
 Rattus norvegicus
-
2.4.1.17 duodenum
-
 Homo sapiens
-
2.4.1.17 duodenum
-
 Rattus norvegicus
-
2.4.1.17 esophagus
-
 Rattus norvegicus
-
2.4.1.17 intestine
-
 Homo sapiens
-
2.4.1.17 intestine
-
 Rattus norvegicus
-
2.4.1.17 jejunum
-
 Homo sapiens
-
2.4.1.17 jejunum
-
 Rattus norvegicus
-
2.4.1.17 kidney
-
 Homo sapiens
-
2.4.1.17 kidney
-
 Rattus norvegicus
-
2.4.1.17 larynx
-
 Homo sapiens
-
2.4.1.17 liver
-
 Rattus norvegicus
-
2.4.1.17 liver constitutively expressed with high interindividual variability of human liver enzyme levels is due to a number of influences, including genetic, tissue-specific, and environmental factors. Homo- and heterozygotic expression of UGT1A6 alleles markedly affects enzyme activity. HNF1 may be responsible for tissue-specific UGT1A6 expression. Multiple environmental factors controll UGT1A6 expression, including the pregnane X receptor, the constitutive androstane receptor, the aryl hydrocarbon receptor, and Nrf2, a bZIP transcription factor mediating stress responses Homo sapiens
-
2.4.1.17 lung
-
 Homo sapiens
-
2.4.1.17 lung
-
 Rattus norvegicus
-
2.4.1.17 ovary
-
 Rattus norvegicus
-
2.4.1.17 stomach
-
 Homo sapiens
-
2.4.1.17 stomach
-
 Rattus norvegicus
-
2.4.1.17 testis
-
 Homo sapiens
-
2.4.1.17 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 acetaminophen + UDP-glucuronate
-
 Rattus norvegicus ?
-
 ?
2.4.1.17 acetaminophen + UDP-glucuronate with human UGT1A6, only monoglucuronides are formed, which, however, can be converted to diglucuronides by UGT1A9 Homo sapiens ?
-
 ?
2.4.1.17 benzo[a]pyrene 3,6-diphenol + UDP-glucuronate converted readily to mono- and diglucuronides Rattus norvegicus ?
-
 ?
2.4.1.17 serotonin + UDP-glucuronate
-
 Rattus norvegicus UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
-
 ?
2.4.1.17 serotonin + UDP-glucuronate highly selective substrate of UGT1A6 in human liver microsomes, with human UGT1A6, only monoglucuronides are formed, which, however, can be converted to diglucuronides by UGT1A9 Homo sapiens UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UGT1A6
-
 Homo sapiens
2.4.1.17 UGT1A6
-
 Rattus norvegicus