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Literature summary extracted from

  • de Oliveira, R.B.; Vaz, A.B.; Alves, R.O.; Liarte, D.B.; Donnici, C.L.; Romanha, A.J.; Zani, C.L.
    Arylfurans as potential Trypanosoma cruzi trypanothione reductase inhibitors (2006), Mem. Inst. Oswaldo Cruz, 101, 169-173.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.12 2,5-bis(3,4,5-trimethoxyphenyl)furan 3% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 2,5-bis(3,4-dimethoxyphenyl)furan 7% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 2,5-bis(4-methoxyphenyl)furan 15% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 2,5-bis(4-nitrophenyl)furan 9% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 2,5-bis[4-(trifluoromethyl)phenyl]furan 10% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 2,5-diphenylfuran 4% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 2-(4-nitrophenyl)furan 34% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine IC50: 0.0065 mM Trypanosoma cruzi
1.8.1.12 4,4'-furan-2,5-diyldibenzonitrile 11% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 4-furan-2-ylbenzenesulfonamide 8% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 4-furan-2-ylbenzonitrile 5% inhibition at 0.02 mg/ml Trypanosoma cruzi
1.8.1.12 N,N'-(furan-2,5-diyldibenzene-4,1-diyl)diacetamide IC50: 0.0485 mM, 54% inhibition at 0.02 mg/ml Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma cruzi trypanothione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.12 TR
-
 Trypanosoma cruzi
1.8.1.12 trypanothione reductase
-
 Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 NADPH
-
 Trypanosoma cruzi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.12 0.0065
-
 IC50: 0.0065 mM Trypanosoma cruzi 3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
1.8.1.12 0.0485
-
 IC50: 0.0485 mM, 54% inhibition at 0.02 mg/ml Trypanosoma cruzi N,N'-(furan-2,5-diyldibenzene-4,1-diyl)diacetamide