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Literature summary extracted from

  • Cooper, C.L.; Lash, T.D.; Jones, M.A.
    Kinetic evaluation of human cloned coproporphyrinogen oxidase using a ring isomer of the natural substrate (2005), Med. Sci. Monit., 11, BR420-BR425.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.3.3 medicine increase of severity of porphyrias with monovinyl accumulation, ability of the increased levels of C-IV to compete with the authentic substrate has important implications for clinical porphyrias Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.3 expression in Escherichia coli BL21(DE3)RIL Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.3 0.00013
-
 Coproporphyrinogen-III with monovinyl product Homo sapiens
1.3.3.3 0.00065
-
 coproporphyrinogen-IV with monovinyl product Homo sapiens
1.3.3.3 0.00068
-
 Coproporphyrinogen-III total product Homo sapiens
1.3.3.3 0.0007
-
 Coproporphyrinogen-III with divinyl product Homo sapiens
1.3.3.3 0.00078
-
 coproporphyrinogen-IV total product Homo sapiens
1.3.3.3 0.00083
-
 coproporphyrinogen-IV with divinyl product Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.3.3 37700
-
 37700, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.3 Ni2+ affinity chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ small amount of the monovinyl intermediate Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-IV + O2 monovinyl intermediate that accumulates before being converted to an isomer Homo sapiens protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.3.3 ? 37700, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 copro'gen oxidase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.3.3 0.0033
-
 Coproporphyrinogen-III with monovinyl product Homo sapiens
1.3.3.3 0.01167
-
 coproporphyrinogen-IV with divinyl product Homo sapiens
1.3.3.3 0.0283
-
 coproporphyrinogen-IV with monovinyl product Homo sapiens
1.3.3.3 0.043
-
 coproporphyrinogen-IV total product Homo sapiens
1.3.3.3 0.055
-
 Coproporphyrinogen-III with divinyl product Homo sapiens
1.3.3.3 0.06
-
 Coproporphyrinogen-III total product Homo sapiens