Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lawrence, R.; Yabe, T.; Haj Mohammadi, S.; Rhodes, J.; McNeely, M.; Liu, J.; Lamperti, E.D.; Toselli, P.A.; Lech, M.; Spear, P.G.; Rosenberg, R.D.; Shworak, N.W.
    The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues (2007), Matrix Biol., 26, 442-455.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.23 gD-type-3-OST-4, DNA and amino acid sequence determination and sequence comparisons, neuronal tissue expression analysis, expression in CHO cells Drosophila melanogaster
2.8.2.29 gD-type-3-OST-2, DNA and amino acid sequence determination and sequence comparisons, neuronal tissue expression analysis Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.23 membrane transmembrane enzyme with a short cytoplasmic tail at the N-terminus Drosophila melanogaster 16020
-
2.8.2.29 membrane transmembrane enzyme with a short cytoplasmic tail at the N-terminus Drosophila melanogaster 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.23 49825
-
 x * 49825, recombinant gD-type-3-OST-4, sequence calculation Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.23 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Drosophila melanogaster
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 mediating the viral cellular entry, overview ?
2.8.2.23 additional information Drosophila melanogaster gD-type-3-OST is essential for a conserved neurogenic signaling pathway regulated by Notch ?
-
 ?
2.8.2.29 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Drosophila melanogaster
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 mediating the viral cellular entry, overview ?
2.8.2.29 additional information Drosophila melanogaster a gD-type-3-OST isozyme is essential for a conserved neurogenic signaling pathway regulated by Notch ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.23 Drosophila melanogaster
-
 isozymes gD-type-3-OST-4 and gD-type-3-OST-1
-
2.8.2.29 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.23 brain gD-type-3-OST-4 is one of the major enzymes Drosophila melanogaster
-
2.8.2.23 additional information neuronal tissue distribution of 3-O-sulfotransferases, overview Drosophila melanogaster
-
2.8.2.23 neuron of trigeminal ganglia, gD-type-3-OST-2 is one of the major enzymes, highly located in neuronal cell bodies not in axons, overview Drosophila melanogaster
-
2.8.2.29 brain gD-type-3-OST-2 is one of the major enzymes Drosophila melanogaster
-
2.8.2.29 additional information neuronal tissue distribution of 3-O-sulfotransferases, overview Drosophila melanogaster
-
2.8.2.29 neuron of trigeminal ganglia, gD-type-3-OST-2 is one of the major enzymes, highly located in neuronal cell bodies not in axons, overview Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.23 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Drosophila melanogaster adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 mediating the viral cellular entry, overview ?
2.8.2.23 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Drosophila melanogaster adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 ?
2.8.2.23 additional information gD-type-3-OST is essential for a conserved neurogenic signaling pathway regulated by Notch Drosophila melanogaster ?
-
 ?
2.8.2.29 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Drosophila melanogaster adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 mediating the viral cellular entry, overview ?
2.8.2.29 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Drosophila melanogaster adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate i.e. HSgD+, 3-O-sulfated motifs that bind the gD envelope protein of Herpes simplex virus 1 ?
2.8.2.29 additional information a gD-type-3-OST isozyme is essential for a conserved neurogenic signaling pathway regulated by Notch Drosophila melanogaster ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.23 ? x * 49825, recombinant gD-type-3-OST-4, sequence calculation Drosophila melanogaster
2.8.2.23 More gD-type-3-OST-4 contains a short N-terminal cytoplasmic tail, a hydrophobic membrane spanning segment, and a SPLAG domain, the cytoplasmic tail contains a polyproline stretch, possibly involved in protein-protein interactions Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.8.2.23 gD-type 3-O-sulfotransferase-4
-
 Drosophila melanogaster
2.8.2.23 gD-type-3-OST-1
-
 Drosophila melanogaster
2.8.2.23 gD-type-3-OST-4
-
 Drosophila melanogaster
2.8.2.23 More the enzyme belongs to the family of 3-O-sulfotransferases Drosophila melanogaster
2.8.2.29 gD-type 3-O-sulfotransferase-2
-
 Drosophila melanogaster
2.8.2.29 gD-type-3-OST-2
-
 Drosophila melanogaster
2.8.2.29 More the enzyme belongs to the family of 3-O-sulfotransferases Drosophila melanogaster