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Literature summary extracted from
- Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits (2006), Life Sci., 78, 785-794.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.9 | additional information | the specific enzyme activity is not affected by cloricromene in vitro and in vivo in liver and kidney | Oryctolagus cuniculus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.13.9 | mitochondrion | - |
Oryctolagus cuniculus | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.9 | kynurenine + NADPH + O2 | Oryctolagus cuniculus | the enzyme is involved in the kynurenine pathway of tryptophan metabolsim, overview | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.9 | Oryctolagus cuniculus | - |
male, 4-month-old diabetic/hyperlipidemic New Zealand White rabbits | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.9 | kidney | - |
Oryctolagus cuniculus | - |
| 1.14.13.9 | liver | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.9 | 0.0004 | - |
activity in kidney | Oryctolagus cuniculus |
| 1.14.13.9 | 0.001 | - |
activity in liver | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.9 | kynurenine + NADPH + O2 | - |
Oryctolagus cuniculus | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
| 1.14.13.9 | kynurenine + NADPH + O2 | the enzyme is involved in the kynurenine pathway of tryptophan metabolsim, overview | Oryctolagus cuniculus | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.9 | NADPH | - |
Oryctolagus cuniculus | |
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