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Literature summary extracted from

  • DAndrea, V.; Perez, L.M.; Sanchez Pozzi, E.J.
    Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide (2005), Life Sci., 77, 683-692.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 silibinin-glucuronide cmpetitive; competitive Rattus norvegicus
2.4.1.17 silymarin competitive Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Rattus norvegicus Q64550
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-glucuronate + p-nitrophenol
-
 Rattus norvegicus UDP + 4-nitrophenyl-alpha-D-glucuronide
-
 ?
2.4.1.17 UDPglucuronate + bilirubin
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 bilirubin-specific UDPGT isozyme 1
-
 Rattus norvegicus
2.4.1.17 HUG-BR1
-
 Rattus norvegicus
2.4.1.17 phenol-metabolizing UDP-glucuronosyltransferase
-
 Rattus norvegicus
2.4.1.17 UDP-glucuronosyltransferase 1A1
-
 Rattus norvegicus
2.4.1.17 UDP-glucuronosyltransferase 1A6
-
 Rattus norvegicus
2.4.1.17 UDPGT
-
 Rattus norvegicus
2.4.1.17 UGT-1A
-
 Rattus norvegicus
2.4.1.17 UGT-1F
-
 Rattus norvegicus
2.4.1.17 UGT1-01
-
 Rattus norvegicus
2.4.1.17 UGT1-06
-
 Rattus norvegicus
2.4.1.17 UGT1.1
-
 Rattus norvegicus
2.4.1.17 UGT1.6
-
 Rattus norvegicus
2.4.1.17 UGT1A
-
 Rattus norvegicus
2.4.1.17 UGT1A1
-
 Rattus norvegicus
2.4.1.17 UGT1A6
-
 Rattus norvegicus
2.4.1.17 UGT1F
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 additional information
-
 additional information Ki-value for silibinin-glucuronide at 37°C, pH 7.8 is 0.016 mg/ml Rattus norvegicus
2.4.1.17 additional information
-
 additional information Ki-value for silibinin-glucuronide at 37°C, pH 8.0 is 0.014 mg/m. Ki-value for silymarin at 37°C, pH 8.0 is 0.051 mg/ml Rattus norvegicus