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Literature summary extracted from

  • Townsend, K.; Evans, K.N.; Campbell, M.J.; Colston, K.W.; Adams, J.S.; Hewison, M.
    Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment (2005), J. Steroid Biochem. Mol. Biol., 97, 103-109.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.15.18 medicine the enzyme is a target in cancer therapy and prevention Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D + NADPH + O2 Homo sapiens extra-renal functions of 1alpha-hydroxylase in vitamin D physiology, regulation, overview 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 additional information Homo sapiens functional analysis of vitamin D metabolism in cancer, locally synthesized 1,25(OH)2D3 may be inefficient in preventing tumor progression, mechanism, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 breast
-
 Homo sapiens
-
1.14.15.18 colon
-
 Homo sapiens
-
1.14.15.18 dendritic cell
-
 Homo sapiens
-
1.14.15.18 epithelial cell
-
 Homo sapiens
-
1.14.15.18 macrophage
-
 Homo sapiens
-
1.14.15.18 additional information altered expression of 1alpha-hydroxylase in different types of neoplasm including breast, prostate and colon cancers, autocrine/paracrine synthesis of 1,25(OH)2D3 is decreased in tumor cells and cell lines Homo sapiens
-
1.14.15.18 prostate gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D + NADPH + O2
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 25-hydroxyvitamin D + NADPH + O2 extra-renal functions of 1alpha-hydroxylase in vitamin D physiology, regulation, overview Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 additional information functional analysis of vitamin D metabolism in cancer, locally synthesized 1,25(OH)2D3 may be inefficient in preventing tumor progression, mechanism, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.18 1alpha-hydroxylase
-
 Homo sapiens
1.14.15.18 25-hydroxyvitamin D-1alpha-hydroxylase
-
 Homo sapiens
1.14.15.18 CYP27B1
-
 Homo sapiens
1.14.15.18 extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.18 NADPH
-
 Homo sapiens