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Literature summary extracted from

  • Mueller-Vieira, U.; Angotti, M.; Hartmann, R.W.
    The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors (2005), J. Steroid Biochem. Mol. Biol., 96, 259-270.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.4 fadrozole in vitro and in vivo inhibition Homo sapiens
1.14.15.4 additional information effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.4 11-deoxycortisol + reduced adrenal ferredoxin + O2 Homo sapiens
-
 cortisol + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 Homo sapiens
-
 aldosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 additional information Homo sapiens effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.4 adrenal gland
-
 Homo sapiens
-
1.14.15.4 NCI-H295R cell adrenocortical tumor cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.4 11-deoxycortisol + reduced adrenal ferredoxin + O2
-
 Homo sapiens cortisol + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
 Homo sapiens aldosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 additional information effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.4 Aldosterone synthase
-
 Homo sapiens
1.14.15.4 CYP11B1
-
 Homo sapiens
1.14.15.4 CYP11B2
-
 Homo sapiens
1.14.15.4 steroid-11beta-hydroxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.4 reduced adrenal ferredoxin
-
 Homo sapiens