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Literature summary extracted from

  • Banasik, M.; Stedeford, T.; Strosznajder, R.P.; Hsu, C.H.; Tanaka, S.; Ueda, K.
    Differential effects of heterocyclic amines on poly(ADP-ribose) polymerase-1 and mono-ADP-ribosyltransferase A (2006), J. Physiol. Pharmacol., 57 Suppl 4, 15-22.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.30 3-amino-1-methyl-5H-pyrido[4,3-b]indole i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM Bos taurus
2.4.2.31 3-amino-1-methyl-5H-pyrido[4,3-b]indole i.e. Trp-P-2, 71% activation at 3 mM Meleagris sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.30 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole i.e. Trp-P-1, 94% inhibition at 5 mM, IC50: 0.22 mM Bos taurus
2.4.2.30 3-amino-1-methyl-5H-pyrido[4,3-b]indole i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM Bos taurus
2.4.2.30 additional information comparison of the effects of heterocyclic amines acting as potent carcinogens on PARP-1 and the arginine-specific mono-ADP-ribosyltransferase A, MART-A, EC 2.4.2.31, overview Bos taurus
2.4.2.31 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole i.e. Trp-P-1, 53% inhibition at 5 mM, IC50: 2.8 mM Meleagris sp.
2.4.2.31 additional information comparison of the effects of heterocyclic amines acting as potent carcinogens on poly(ADP-ribose) polymerase-1, PARP-1, EC 2.4.2.30, and the arginine-specific mono-ADP-ribosyltransferase A, overview Meleagris sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.30 Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Bos taurus the enzyme is a DNA repair enzyme nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Bos taurus
-
-
-
2.4.2.31 Meleagris sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.30 thymus
-
 Bos taurus
-
2.4.2.31 erythrocyte
-
 Meleagris sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor the enzyme is a DNA repair enzyme Bos taurus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + histone H2B
-
 Bos taurus nicotinamide + (ADP-D-ribosyl)-histone H2B
-
 ?
2.4.2.31 histone H2B + NAD+
-
 Meleagris sp. Nomega-[(2'-phospho-ADP)-D-ribosyl]-histone H2B-L-arginine + nicotinamide
-
 ?
2.4.2.31 additional information the enzyme is involved in signal transduction and cytoskeletal realignment Meleagris sp. ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 PARP-1
-
 Bos taurus
2.4.2.30 poly(ADP-ribose) polymerase-1
-
 Bos taurus
2.4.2.31 arginine-specific mono-ADP-ribosyltransferase A
-
 Meleagris sp.
2.4.2.31 MART-A
-
 Meleagris sp.
2.4.2.31 mono-ADP-ribosyltransferase A
-
 Meleagris sp.

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.30 37
-
 assay at Bos taurus
2.4.2.31 30
-
 assay at Meleagris sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.30 8
-
 assay at Bos taurus
2.4.2.31 7
-
 assay at Meleagris sp.

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.2.30 0.22
-
 i.e. Trp-P-1, 94% inhibition at 5 mM, IC50: 0.22 mM Bos taurus 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole
2.4.2.30 2.2
-
 i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM Bos taurus 3-amino-1-methyl-5H-pyrido[4,3-b]indole
2.4.2.31 2.8
-
 i.e. Trp-P-1, 53% inhibition at 5 mM, IC50: 2.8 mM Meleagris sp. 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole