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Literature summary extracted from

  • Robert, R.; Norez, C.; Becq, F.
    Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells (2005), J. Physiol., 568, 483-495.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.1.6 5-hydroxytryptamine activates CFTR in myocytes Mus musculus
5.6.1.6 A23187
-
 Mus musculus
5.6.1.6 cAMP stimulates Mus musculus
5.6.1.6 forskolin stimulates, potentiation in the presence of genistein Mus musculus
5.6.1.6 genistein stimulates, potentiation in the presence of forskolin Mus musculus
5.6.1.6 IBMX
-
 Mus musculus
5.6.1.6 isoproterenol stimulates Mus musculus
5.6.1.6 MPB-07 stimulates Mus musculus
5.6.1.6 MPB-91 stimulates Mus musculus
5.6.1.6 Vasoactive intestinal peptide stimulates Mus musculus

Application

EC Number Application Comment Organism
5.6.1.6 medicine novel mechanism for regulation of the vascular tone by cAMP-dependent CFTR chloride channels in vascular smooth muscle cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
5.6.1.6 additional information CFTR knockout mice B6, aortas significantly more constricted than control arteries, less sensitive to the relaxing action of VIP, and fail to relax in the presence of CFTR activators Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.6 CFTRinh-172
-
 Mus musculus
5.6.1.6 diphenylamine-2,2'-dicarboxylic acid fully inhibits Mus musculus
5.6.1.6 glibenclamide fully inhibits Mus musculus
5.6.1.6 additional information not inhibited by calixarene Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.6 membrane
-
 Mus musculus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.1.6 Ca2+ stimulates Mus musculus
5.6.1.6 K+ activates CFTR in myocytes Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.6 aorta
-
 Mus musculus
-
5.6.1.6 myocyte
-
 Mus musculus
-
5.6.1.6 vascular smooth muscle cell
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 CFTR
-
 Mus musculus