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Literature summary extracted from

  • Loehle, J.A.; Cornish, V.; Wakefield, L.; Doll, M.A.; Neale, J.R.; Zang, Y.; Sim, E.; Hein, D.W.
    N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice (2006), J. Pharmacol. Exp. Ther., 319, 724-728.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 tissue-specific expression analysis of isozyme NAT1 Mus musculus
2.3.1.5 tissue-specific expression analysis of isozyme NAT2 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.5 additional information construction of NAT2 knockout mice, phenotype, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.5 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobiphenyl Mus musculus substrate of isozyme NAT2 in liver cytosol N-acetyl-4-aminobiphenyl + CoA
-
 ?
2.3.1.5 acetyl-CoA + an arylamine Mus musculus
-
 CoA + an N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + N-hydroxy-4-aminobiphenyl Mus musculus substrate of isozyme NAT2 in liver cytosol N-acetyl-N-hydroxy-4-aminobiphenyl + CoA
-
 ?
2.3.1.5 additional information Mus musculus the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Mus musculus P50294 isozyme NAT1; male mice, isozyme NAT1
-
2.3.1.5 Mus musculus P50295 isozyme NAT2; male mice, isozyme NAT2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 bladder
-
 Mus musculus
-
2.3.1.5 gut
-
 Mus musculus
-
2.3.1.5 liver
-
 Mus musculus
-
2.3.1.5 additional information broad tissue distribution of isozyme NAT1, tissue-specific expression analysis of isozyme NAT1 Mus musculus
-
2.3.1.5 additional information broad tissue distribution of isozyme NAT2, tissue-specific expression analysis of isozymes NAT2 Mus musculus
-
2.3.1.5 pancreas
-
 Mus musculus
-
2.3.1.5 prostate gland
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
 Mus musculus CoA + N-acetyl-4-aminobenzoic acid
-
 ?
2.3.1.5 acetyl-CoA + 4-aminobiphenyl substrate of isozyme NAT2 in liver cytosol Mus musculus N-acetyl-4-aminobiphenyl + CoA
-
 ?
2.3.1.5 acetyl-CoA + 4-aminobiphenyl substrate of isozyme NAT2 Mus musculus N-acetyl-4-aminobiphenyl + CoA
-
 ?
2.3.1.5 acetyl-CoA + an arylamine
-
 Mus musculus CoA + an N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + isoniazid
-
 Mus musculus CoA + an N-acetylisoniazid
-
 ?
2.3.1.5 acetyl-CoA + N-hydroxy-4-aminobiphenyl substrate of isozyme NAT2 in liver cytosol Mus musculus N-acetyl-N-hydroxy-4-aminobiphenyl + CoA
-
 ?
2.3.1.5 acetyl-CoA + N-hydroxy-4-aminobiphenyl substrate of isozyme NAT2, O-acetylation activity of NAT2 Mus musculus N-hydroxy-O-acetyl-4-aminobiphenyl + CoA
-
 ?
2.3.1.5 additional information the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 NAT
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.5 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.5 7.4
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.5 acetyl-CoA
-
 Mus musculus