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Literature summary extracted from

  • Shimomura, Y.; Honda, T.; Shiraki, M.; Murakami, T.; Sato, J.; Kobayashi, H.; Mawatari, K.; Obayashi, M.; Harris, R.A.
    Branched-chain amino acid catabolism in exercise and liver disease (2006), J. Nutr., 136, 250S-253S.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.4 alpha-Ketoisocaproate promotes dissociation of the BCKDH kinase from the BCKDH complex, consistent with activation of BCKDH complex Rattus norvegicus
1.2.4.4 additional information endurance exercise activates the BCKDH complex Homo sapiens
1.2.4.4 additional information endurance exercise activates the BCKDH complex Rattus norvegicus
1.2.4.4 tumor necrosis factor-alpha promotes dissociation of the BCKDH kinase from the BCKDH complex in rat liver, resulting in activation of the BCKDH complex Rattus norvegicus

Application

EC Number Application Comment Organism
1.2.4.4 medicine activation of the BCKDH complex appears responsible for the increase in branched-chain amino acid catabolism caused by exercise and liver cirrhosis, branched-chain amino acid administration improves protein turnover in humans with liver cirrhosis, suggesting that branched-chain amino acid supplements are appropriate for patients with liver cirrhosis, branched-chain amino acid administration in patients with acute liver failure, especially those with high serum branched-chain amino acid concentrations, may not be appropriate because of the likelihood of branched-chain amino acid overload Homo sapiens
1.2.4.4 medicine activation of the BCKDH complex appears responsible for the increase in branched-chain amino acid catabolism caused by exercise and liver cirrhosis, branched-chain amino acid administration improves protein turnover in rats with liver cirrhosis, suggesting that branched-chain amino acid supplements are appropriate for patients with liver cirrhosis Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.4.4 mitochondrion
-
 Homo sapiens 5739
-
1.2.4.4 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.4 Homo sapiens
-
-
-
1.2.4.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.4 liver
-
 Homo sapiens
-
1.2.4.4 liver
-
 Rattus norvegicus
-
1.2.4.4 skeletal muscle
-
 Homo sapiens
-
1.2.4.4 skeletal muscle
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
1.2.4.4 BCKDH
-
 Homo sapiens
1.2.4.4 BCKDH
-
 Rattus norvegicus
1.2.4.4 branched-chain alpha-keto acid dehydrogenase complex
-
 Homo sapiens
1.2.4.4 branched-chain alpha-keto acid dehydrogenase complex
-
 Rattus norvegicus