Any feedback?
Literature summary extracted from
- Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications (2007), J. Neurosci. Res., 85, 845-854.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.9 | UPF 648 | in vivo inhibition | Mus musculus |  |
| 1.14.13.9 | UPF 648 | in vivo inhibition | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.9 | kynurenine + NADPH + O2 | Mus musculus | enzyme inhibition in immature rats shifts cerebral kynurenine pathway metabolism toward increased kynurenic acid formation, overview | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
| 1.14.13.9 | kynurenine + NADPH + O2 | Rattus norvegicus | enzyme inhibition in immature rats shifts cerebral kynurenine pathway metabolism toward increased kynurenic acid formation, overview | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
| 1.14.13.9 | additional information | Mus musculus | the kynurenine pathway of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid and, in a competing branch, the free radical generator 3-hydroxykynurenine and the excitotoxin quinolinic acid, newborn mice delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia show further enhanced brain kynurenic acid levels, overview | ? | - |
? | |
| 1.14.13.9 | additional information | Rattus norvegicus | the kynurenine pathway of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid and, in a competing branch, the free radical generator 3-hydroxykynurenine and the excitotoxin quinolinic acid, rat pups delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia show further enhanced brain kynurenic acid levels, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.9 | Mus musculus | - |
- |
- |
| 1.14.13.9 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.9 | brain | - |
Mus musculus | - |
| 1.14.13.9 | brain | - |
Rattus norvegicus | - |
| 1.14.13.9 | liver | - |
Mus musculus | - |
| 1.14.13.9 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.9 | additional information | - |
- |
Mus musculus |
| 1.14.13.9 | additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.9 | kynurenine + NADPH + O2 | - |
Mus musculus | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
| 1.14.13.9 | kynurenine + NADPH + O2 | - |
Rattus norvegicus | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
| 1.14.13.9 | kynurenine + NADPH + O2 | enzyme inhibition in immature rats shifts cerebral kynurenine pathway metabolism toward increased kynurenic acid formation, overview | Mus musculus | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
| 1.14.13.9 | kynurenine + NADPH + O2 | enzyme inhibition in immature rats shifts cerebral kynurenine pathway metabolism toward increased kynurenic acid formation, overview | Rattus norvegicus | 3-hydroxy-kynurenine + NADP+ + H2O | - |
? | |
| 1.14.13.9 | additional information | the kynurenine pathway of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid and, in a competing branch, the free radical generator 3-hydroxykynurenine and the excitotoxin quinolinic acid, newborn mice delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia show further enhanced brain kynurenic acid levels, overview | Mus musculus | ? | - |
? | |
| 1.14.13.9 | additional information | the kynurenine pathway of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid and, in a competing branch, the free radical generator 3-hydroxykynurenine and the excitotoxin quinolinic acid, rat pups delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia show further enhanced brain kynurenic acid levels, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.13.9 | kynurenine 3-hydroxylase | - |
Mus musculus |
| 1.14.13.9 | kynurenine 3-hydroxylase | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.9 | NADPH | - |
Mus musculus | |
| 1.14.13.9 | NADPH | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
