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Literature summary extracted from

  • Uboha, N.V.; Flajolet, M.; Nairn, A.C.; Picciotto, M.R.
    A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth (2007), J. Neurosci., 27, 4413-4423.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Rattus norvegicus
2.7.11.17 additional information CaMKI activation by phosphorylation through CaMKK, the CaMK kinase Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 expression of GST-tagged CaMKI in Escherichia coli Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Rattus norvegicus
2.7.11.17 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + microtubule affinity regulating kinase 2 Rattus norvegicus CaMKIalpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth/axonal extension ADP + phosphorylated microtubule affinity regulating kinase 2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein CaMKI activation by phosphorylation through CaMKK, the CaMK kinase Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.17 recombinant GST-tagged CaMKI from Escherichia coli by glutathione affinity chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain expression analysis for CaMKI Rattus norvegicus
-
2.7.11.17 hippocampus primary cells Rattus norvegicus
-
2.7.11.17 neuron hippocampal Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + microtubule affinity regulating kinase 2 CaMKIalpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth/axonal extension Rattus norvegicus ADP + phosphorylated microtubule affinity regulating kinase 2
-
 ?
2.7.11.17 ATP + microtubule affinity regulating kinase 2 i.e. MARK2, recombinant myc-tagged MARK2 expressed in HEK-293 cells, mutational determination of phosphorylation sites, overview Rattus norvegicus ADP + phosphorylated microtubule affinity regulating kinase 2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium- and calmodulin-dependent kinase Ialpha
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.17 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.17 7.6
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus