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Literature summary extracted from

  • He, X.; Jenner, A.M.; Ong, W.Y.; Farooqui, A.A.; Patel, S.C.
    Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury (2006), J. Neuropathol. Exp. Neurol., 65, 652-663.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.25 lovastatin induces and activates the enzyme, acts neuroprotectively in hippocampus after kainate injury, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.25 cholesterol + reduced adrenodoxin + O2 Rattus norvegicus
-
 24-hydroxycholesterol + oxidized adrenodoxin + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Rattus norvegicus
-
 Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 hippocampus after kainate lesions Rattus norvegicus
-
1.14.14.25 neuron hippocampal Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + reduced adrenodoxin + O2
-
 Rattus norvegicus 24-hydroxycholesterol + oxidized adrenodoxin + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 NADPH
-
 Rattus norvegicus