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Literature summary extracted from

  • Martyniuk, C.J.; Chang, J.P.; Trudeau, V.L.
    The effects of GABA agonists on glutamic acid decarboxylase, GABA-transaminase, activin, salmon gonadotrophin-releasing hormone and tyrosine hydroxylase mRNA in the goldfish (Carassius auratus) neuroendocrine brain (2007), J. Neuroendocrinol., 19, 390-396.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.1.1.15 medicine injection of gamma-aminobutanoate agonists baclofen and muscimol increases luteinising hormone in serum after 6 h. Intraperitoneal treatment with gamma-aminobutanaote A agonist muscimol decreases mRNA of isoform GAD65 approximately 10fold, gamma-aminobutanaote transaminase approximately 15fold and tyrosine hydroxylase approximately 3fold in telencephalon. Intraperitoneal treatment with gamma-aminobutanaote B agonist baclofen reduces mRNA levels of isoform GAD67 approximately 2fold and gamma-aminobutanaote transaminase approximately 2fold in hypothalamus Carassius auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 Baclofen injection of 0.01 mg/g body weight reduces GABA-T mRNA level 2fold; i.p. injection of sexually regressed female goldfish results in significant increase in serum luteinising hormone after 6 h. About 2fold decrease both in glutamic acid decarboxylase 67 and gamma-aminobutanoate transaminase mRNa in the hypothalamus Carassius auratus
2.6.1.19 Muscimol injection of 0.001 mg/g body weight reduces GABA-T mRNA level 15fold; i.p. injection of sexually regressed female goldfish results in significant increase in serum luteinising hormone after 6 h. About 10fold decrease in glutamic acid decarboxylase 65 and 15fold in gamma-aminobutanoate transaminase mRNa in the hypothalamus Carassius auratus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Carassius auratus
-
-
-
4.1.1.15 Carassius auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 brain
-
 Carassius auratus
-
2.6.1.19 hypothalamus
-
 Carassius auratus
-
2.6.1.19 telencephalon
-
 Carassius auratus
-
4.1.1.15 brain
-
 Carassius auratus
-
4.1.1.15 hypothalamus intraperitoneal treatment with gamma-aminobutanaote B agonist baclofen reduces mRNA levels of isoform GAD67 approximately 2fold and gamma-aminobutanaote transaminase approximately 2fold Carassius auratus
-
4.1.1.15 telencephalon intraperitoneal treatment with gamma-aminobutanaote A agonist muscimol decreases mRNA of isoform GAD65 approximately 10fold, gamma-aminobutanaote transaminase approximately 15fold and tyrosine hydroxylase approximately 3fold Carassius auratus
-

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 GABA-T
-
 Carassius auratus
2.6.1.19 GABA-transaminase
-
 Carassius auratus