Literature summary extracted from

Patel, A.B.; de Graaf, R.A.; Martin, D.L.; Battaglioli, G.; Behar, K.L.
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo (2006), J. Neurochem., 97, 385-396.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.6.1.19	gabaculine	IC50: 0.0018 mM, potent and irreversible inhibitor	Rattus norvegicus
2.6.1.19	vigabatrin	IC50: 0.35 mM	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.6.1.19	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.6.1.19	brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.6.1.19	4-aminobutanoate + 2-oxoglutarate	-	Rattus norvegicus	4-oxobutanoate + L-glutamate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.6.1.19	GABA-T	-	Rattus norvegicus

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.6.1.19	0.0018	-	IC50: 0.0018 mM, potent and irreversible inhibitor	Rattus norvegicus	gabaculine
2.6.1.19	0.35	-	IC50: 0.35 mM	Rattus norvegicus	vigabatrin

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Release 2023.1 (January 2023)