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Literature summary extracted from

  • Wang Xue, Q.; Yu Shan, P.
    Novel regulation of Na, K-ATPase by Src tyrosine kinases in cortical neurons (2005), J. Neurochem., 93, 1515-1523.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.13 dephostatin
-
 Mus musculus
7.2.2.13 K+ extracellular Mus musculus
7.2.2.13 Lyn kinase Lyn kinase directly binds to the Na+,K+-ATPase alpha3 subunit for regulation of activity Mus musculus
7.2.2.13 Yes kinase regulator of the Na+,K+-ATPase activity Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 genistein tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase Mus musculus
7.2.2.13 herbimycin A tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase Mus musculus
7.2.2.13 lavendustin A tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase Mus musculus
7.2.2.13 Lyn kinase Lyn kinase directly binds to the Na+,K+-ATPase alpha3 subunit for regulation of activity Mus musculus
7.2.2.13 Ouabain
-
 Mus musculus
7.2.2.13 PP1 Src kinase inhibitor Mus musculus
7.2.2.13 strophanthidin tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase Mus musculus
7.2.2.13 Yes kinase regulator of the Na+,K+-ATPase activity Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ADP + phosphate + Na+/out Mus musculus each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP ATP + H2O + Na+/in
-
 ?
7.2.2.13 ATP + H2O + K+/in Mus musculus
-
 ADP + phosphate + K+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ADP + phosphate + Na+/out
-
 Mus musculus ATP + H2O + Na+/in
-
 ?
7.2.2.13 ADP + phosphate + Na+/out each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP Mus musculus ATP + H2O + Na+/in
-
 ?
7.2.2.13 ATP + H2O + K+/in
-
 Mus musculus ADP + phosphate + K+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na+,K+-ATPase
-
 Mus musculus
7.2.2.13 Na+,K+-pump
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7.2.2.13 0.076
-
 strophanthidin IC50 Mus musculus