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Literature summary extracted from

  • Zhang, C.; Ondeyka, J.G.; Herath, K.B.; Guan, Z.; Collado, J.; Pelaez, F.; Leavitt, P.S.; Gurnett, A.; Nare, B.; Liberator, P.; Singh, S.B.
    Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity (2006), J. Nat. Prod., 69, 710-712.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 4-methoxy-3,6-diphenylcyclohexa-3,5-diene-1,2-dione isolated from a microbial extract of a Phoma sp. Eimeria tenella
2.7.11.12 4-methoxy-3,6-diphenylcyclohexa-3,5-diene-1,2-dione isolated from a microbial extract of a Phoma sp. Toxoplasma gondii
2.7.11.12 4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine a synthetic compound Eimeria tenella
2.7.11.12 4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine a synthetic compound Toxoplasma gondii
2.7.11.12 6'-methoxy-1,1':4',1''-terphenyl-2,2',5'-triol isolated from a microbial extract of a Phoma sp. Eimeria tenella
2.7.11.12 6'-methoxy-1,1':4',1''-terphenyl-2,2',5'-triol isolated from a microbial extract of a Phoma sp. Toxoplasma gondii
2.7.11.12 6'-methoxy-1,1':4',1''-terphenyl-2,2',5,5'-tetrol isolated from a microbial extract of a Phoma sp. Eimeria tenella
2.7.11.12 6'-methoxy-1,1':4',1''-terphenyl-2,2',5,5'-tetrol isolated from a microbial extract of a Phoma sp. Toxoplasma gondii
2.7.11.12 terferol isolated from a microbial extract of a Phoma sp. Eimeria tenella
2.7.11.12 terferol isolated from a microbial extract of a Phoma sp. Toxoplasma gondii

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.12 Mg2+
-
 Eimeria tenella
2.7.11.12 Mg2+
-
 Toxoplasma gondii

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Eimeria tenella
-
-
-
2.7.11.12 Toxoplasma gondii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 ATP + a peptide
-
 Eimeria tenella ADP + a phosphorylated peptide
-
 ?
2.7.11.12 ATP + a peptide
-
 Toxoplasma gondii ADP + a phosphorylated peptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 PKG
-
 Eimeria tenella
2.7.11.12 PKG
-
 Toxoplasma gondii

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.12 ATP
-
 Eimeria tenella
2.7.11.12 ATP
-
 Toxoplasma gondii

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.12 0.000001
-
-
 Eimeria tenella 4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine
2.7.11.12 0.00021
-
-
 Toxoplasma gondii 4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine
2.7.11.12 0.0009
-
-
 Eimeria tenella 4-methoxy-3,6-diphenylcyclohexa-3,5-diene-1,2-dione
2.7.11.12 0.0039
-
-
 Eimeria tenella terferol
2.7.11.12 0.0052
-
-
 Eimeria tenella 6'-methoxy-1,1':4',1''-terphenyl-2,2',5'-triol
2.7.11.12 0.0058
-
-
 Eimeria tenella 6'-methoxy-1,1':4',1''-terphenyl-2,2',5,5'-tetrol
2.7.11.12 0.0095
-
-
 Toxoplasma gondii 6'-methoxy-1,1':4',1''-terphenyl-2,2',5,5'-tetrol
2.7.11.12 0.0104
-
-
 Toxoplasma gondii 6'-methoxy-1,1':4',1''-terphenyl-2,2',5'-triol
2.7.11.12 0.0268
-
-
 Toxoplasma gondii terferol