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Literature summary extracted from

  • Carroll, A.R.; Ngo, A.; Quinn, R.J.; Redburn, J.; Hooper, J.N.
    Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp (2005), J. Nat. Prod., 68, 804-806.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.2.1.11 medicine target for antibiotic development Helicobacter pylori

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.11 expression in Escherichia coli Helicobacter pylori

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.11 petrosamine B 50% inhibition at 0.306 mM. Petrosamine B is a pyridoacridine alkaloid isolated from the sponge Oceanapia sp.; isolated from the methanol extract of the saustralian sponge Oceanapia sp. Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+ Helicobacter pylori
-
 L-4-aspartyl phosphate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Helicobacter pylori
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.11 Ni-affinity chromatography Helicobacter pylori

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Helicobacter pylori L-4-aspartyl phosphate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.11 Asd
-
 Helicobacter pylori
1.2.1.11 aspartate semialdehyde dehydrogenase
-
 Helicobacter pylori
1.2.1.11 aspartate-semialdehyde dehydrogenase
-
 Helicobacter pylori
1.2.1.11 aspartyl semialdehyde dehydrogenase
-
 Helicobacter pylori

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.11 23
-
 activity assay Helicobacter pylori

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.11 8
-
 activity assay Helicobacter pylori

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.11 NADP+
-
 Helicobacter pylori
1.2.1.11 NADPH
-
 Helicobacter pylori

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.2.1.11 0.306
-
-
 Helicobacter pylori petrosamine B