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Literature summary extracted from

  • Annoura, T.; Nara, T.; Makiuchi, T.; Hashimoto, T.; Aoki, T.
    The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions (2005), J. Mol. Evol., 60, 113-127.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.98.1 additional information an ancient common ancestor of Euglenozoa had a mitochondrial DHOD whose descendant exists in Euglena gracilis Euglena gracilis
1.3.98.1 additional information Bodo saliens has an ACT/DHOD gene fusion encoding aspartate carbamoyltransferase, the second enzyme of the de novo pyrimidine pathway, and DHOD Neobodo saliens
1.3.98.1 additional information the cytosolic DHOD gene acquired may have contributed to adaptation to anaerobiosis in the kinetoplastid lineage and further contributes to the subsequent establishment of parasitism in a trypanosomatid ancestor Trypanosoma cruzi

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.98.1
-
Euglena gracilis

Protein Variants

EC Number Protein Variants Comment Organism
1.3.98.1 additional information DHOD-knockout Trypanosoma cruzi do not express the enzyme protein and can not survive even in the presence of pyrimidine nucleosides, suggesting a vital role of fumarate reductase activity in the regulation of cellular redox balance Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.98.1 cytosol
-
Trypanosoma cruzi 5829
-
1.3.98.1 cytosol
-
Neobodo saliens 5829
-
1.3.98.1 cytosol
-
Parabodo caudatus 5829
-
1.3.98.1 mitochondrion
-
Euglena gracilis 5739
-
1.3.98.1 mitochondrion
-
Trypanosoma cruzi 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.98.1 Euglena gracilis
-
-
-
1.3.98.1 Euglena gracilis Q75XR0
-
-
1.3.98.1 Neobodo saliens
-
-
-
1.3.98.1 Neobodo saliens Q6F4D1
-
-
1.3.98.1 Parabodo caudatus Q6F4D0
-
-
1.3.98.1 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.98.1 dihydroorotate + fumarate
-
Euglena gracilis orotate + ?
-
?
1.3.98.1 dihydroorotate + fumarate
-
Trypanosoma cruzi orotate + ?
-
?
1.3.98.1 dihydroorotate + fumarate
-
Neobodo saliens orotate + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.3.98.1 ACT/DHOD
-
Neobodo saliens
1.3.98.1 ACT/DHOD gene fusion encoding aspartate carbamoyltransferase and dihyroorotate dehydrogenase Neobodo saliens
1.3.98.1 DHOD
-
Euglena gracilis
1.3.98.1 DHOD
-
Trypanosoma cruzi
1.3.98.1 DHOD
-
Neobodo saliens
1.3.98.1 DHOD
-
Parabodo caudatus