BRENDA - Enzyme Database show

Structure-function analysis of a bacterial deoxyadenosine kinase reveals the basis for substrate specificity

Welin, M.; Wang, L.; Eriksson, S.; Eklund, H.; J. Mol. Biol. 366, 1615-1623 (2007)

Data extracted from this reference:

Crystallization (Commentary)
EC Number
Crystallization
Organism
2.7.1.76
in complex with deoxyadenosine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate, as well as with products 2'-deoxycytidine 5'-phosphate and 2'-deoxycytidine 5'-diphosphate. Both deoxyadenosine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate bind to the enzyme in a feedback-inhibitory manner with the deoxyribonucleoside part in the deoxyribonucleoside binding site and the triphosphates in the P-loop. Superposition with human counterparts deoxyguanosine kinase and deoxycytidine kinase. Overall structures are very similar with a few amino acid alterations in the proximity of the active site; sitting drop vapour diffusion method using 24% (w/v) PEG 3350 and 0.2 M KSCN
Mycoplasma mycoides
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.76
dATP
feedback inhibitor
Mycoplasma mycoides
2.7.1.76
dCTP
feedback inhibitor
Mycoplasma mycoides
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.1.76
25000
-
2 * 25000, Superdex 75 column gel filtration
Mycoplasma mycoides
2.7.1.76
50000
-
Superdex 75 column gel filtration
Mycoplasma mycoides
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.76
Mycoplasma mycoides
-
subspecies Mycoplasma mycoides mycoides
-
2.7.1.76
Mycoplasma mycoides
Q93IG4
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.7.1.76
Superdex 75 column gel filtration
Mycoplasma mycoides
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.76
ATP + 1-beta-D-arabinofuranosyl cytosine
3% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 1-beta-D-arabinofuranosyl cytosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 1-beta-D-arabinofuranosyl cytosine
3% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 1-beta-D-arabinofuranosyl cytosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 1-beta-D-arabinofuranosyl uracil
0.3% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 1-beta-D-arabinofuranosyl uracil 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2',2'-difluoro-2'-deoxycytidine
20% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',2'-difluoro-2'-deoxycytidine monophosphate
-
-
-
?
2.7.1.76
ATP + 2',2'-difluoro-2'-deoxycytidine
20% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2',2'-difluoro-2'-deoxyguanosine
24% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',2'-difluoro-2'-deoxyguanosine monophosphate
-
-
-
?
2.7.1.76
ATP + 2',2'-difluoro-2'-deoxyguanosine
24% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',2'-difluoro-2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyadenosine
1.5% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyadenosine monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyadenosine
1.5% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyadenosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxycytidine
0.1% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxycytidine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyguanosine
0.5% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyguanosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyinoosine
3.9% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyinosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyinosine
3.9% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyinosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxyadenosine
-
675428
Mycoplasma mycoides
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxycytidine
81% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxyguanosine
97% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxyinosine
116% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxyinosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxythymidine
0.01% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxyuridine
0.9% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-fluoro-arabinosyl adenine
15% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-fluoro-arabinosyl adenine monophosphate
-
-
-
?
2.7.1.76
ATP + 2'-fluoro-arabinosyl adenine
15% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-fluoro-arabinosyl adenine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2-chloro-2'-deoxyadenosine
111% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2-chloro-2'-deoxyadenosine monophosphate
-
-
-
?
2.7.1.76
ATP + 2-chloro-2'-deoxyadenosine
111% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 9-beta-D-arabinofuranosyl adenine
77% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 9-beta-D-arabinofuranosyl adenine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 9-beta-D-arabinofuranosyl adenine
77% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 9-beta-D-arabinofuranosyl adenine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 9-beta-D-arabinofuranosyl guanine
6% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 9-beta-D-arabinofuranosyl guanine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 9-beta-D-arabinofuranosyl guanine
6% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 9-beta-D-arabinofuranosyl guanine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + adenosine
7.4% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + AMP
-
-
-
?
2.7.1.76
ATP + adenosine
7.4% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + adenosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + cytidine
0.1% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + cytidine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + deoxyadenosine
100% activity
675428
Mycoplasma mycoides
ADP + dAMP
-
-
-
?
2.7.1.76
ATP + deoxycytosine
81% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + dCMP
-
-
-
?
2.7.1.76
ATP + deoxyguanosine
97% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + dGMP
-
-
-
?
2.7.1.76
ATP + deoxyinosine
116% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + dIMP
-
-
-
?
2.7.1.76
ATP + deoxyuridine
0.9% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + dUMP
-
-
-
?
2.7.1.76
ATP + guanosine
5.5% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + GMP
-
-
-
?
2.7.1.76
ATP + guanosine
5.5% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + guanosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + inosine
5.9% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + IMP
-
-
-
?
2.7.1.76
ATP + inosine
5.9% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + inosine monophosphate
-
-
-
?
2.7.1.76
ATP + penciclovir
1.4% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + ?
-
-
-
?
2.7.1.76
CTP + deoxyadenosine
57% activity compared to ATP
675428
Mycoplasma mycoides
CDP + dAMP
-
-
-
?
2.7.1.76
dATP + deoxyadenosine
2% activity compared to ATP
675428
Mycoplasma mycoides
dADP + dAMP
-
-
-
?
2.7.1.76
dCTP + deoxyadenosine
106% activity compared to ATP
675428
Mycoplasma mycoides
dCDP + dAMP
-
-
-
?
2.7.1.76
dTTP + deoxyadenosine
44% activity compared to ATP
675428
Mycoplasma mycoides
dTDP + dAMP
-
-
-
?
2.7.1.76
additional information
less than 1% activity with dGTP, deoxyuridine, deoxythymidine, 1-beta-D-arabinofuranosyl uracil, 2',3'-dideoxyguanosine, 2',3'-dideoxycytidine, cytidine, acyclovir, ganciclovir, 2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil, and 5-fluoro-2'-deoxyuridine
675428
Mycoplasma mycoides
?
-
-
-
-
2.7.1.76
UTP + deoxyadenosine
22% activity compared to ATP
675428
Mycoplasma mycoides
UDP + dAMP
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
2.7.1.76
dimer
2 * 25000, Superdex 75 column gel filtration
Mycoplasma mycoides
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.76
ATP
-
Mycoplasma mycoides
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.76
ATP
-
Mycoplasma mycoides
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
2.7.1.76
in complex with deoxyadenosine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate, as well as with products 2'-deoxycytidine 5'-phosphate and 2'-deoxycytidine 5'-diphosphate. Both deoxyadenosine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate bind to the enzyme in a feedback-inhibitory manner with the deoxyribonucleoside part in the deoxyribonucleoside binding site and the triphosphates in the P-loop. Superposition with human counterparts deoxyguanosine kinase and deoxycytidine kinase. Overall structures are very similar with a few amino acid alterations in the proximity of the active site
Mycoplasma mycoides
2.7.1.76
sitting drop vapour diffusion method using 24% (w/v) PEG 3350 and 0.2 M KSCN
Mycoplasma mycoides
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.76
dATP
feedback inhibitor
Mycoplasma mycoides
2.7.1.76
dCTP
feedback inhibitor
Mycoplasma mycoides
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.1.76
25000
-
2 * 25000, Superdex 75 column gel filtration
Mycoplasma mycoides
2.7.1.76
50000
-
Superdex 75 column gel filtration
Mycoplasma mycoides
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.1.76
Superdex 75 column gel filtration
Mycoplasma mycoides
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.76
ATP + 1-beta-D-arabinofuranosyl cytosine
3% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 1-beta-D-arabinofuranosyl cytosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 1-beta-D-arabinofuranosyl cytosine
3% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 1-beta-D-arabinofuranosyl cytosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 1-beta-D-arabinofuranosyl uracil
0.3% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 1-beta-D-arabinofuranosyl uracil 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2',2'-difluoro-2'-deoxycytidine
20% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',2'-difluoro-2'-deoxycytidine monophosphate
-
-
-
?
2.7.1.76
ATP + 2',2'-difluoro-2'-deoxycytidine
20% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2',2'-difluoro-2'-deoxyguanosine
24% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',2'-difluoro-2'-deoxyguanosine monophosphate
-
-
-
?
2.7.1.76
ATP + 2',2'-difluoro-2'-deoxyguanosine
24% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',2'-difluoro-2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyadenosine
1.5% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyadenosine monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyadenosine
1.5% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyadenosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxycytidine
0.1% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxycytidine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyguanosine
0.5% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyguanosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyinoosine
3.9% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyinosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2',3'-dideoxyinosine
3.9% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2',3'-dideoxyinosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxyadenosine
-
675428
Mycoplasma mycoides
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxycytidine
81% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxyguanosine
97% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxyinosine
116% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxyinosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxythymidine
0.01% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-deoxyuridine
0.9% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 2'-fluoro-arabinosyl adenine
15% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-fluoro-arabinosyl adenine monophosphate
-
-
-
?
2.7.1.76
ATP + 2'-fluoro-arabinosyl adenine
15% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2'-fluoro-arabinosyl adenine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 2-chloro-2'-deoxyadenosine
111% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2-chloro-2'-deoxyadenosine monophosphate
-
-
-
?
2.7.1.76
ATP + 2-chloro-2'-deoxyadenosine
111% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 9-beta-D-arabinofuranosyl adenine
77% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 9-beta-D-arabinofuranosyl adenine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 9-beta-D-arabinofuranosyl adenine
77% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 9-beta-D-arabinofuranosyl adenine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + 9-beta-D-arabinofuranosyl guanine
6% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + 9-beta-D-arabinofuranosyl guanine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + 9-beta-D-arabinofuranosyl guanine
6% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + 9-beta-D-arabinofuranosyl guanine 5'-phosphate
-
-
-
?
2.7.1.76
ATP + adenosine
7.4% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + AMP
-
-
-
?
2.7.1.76
ATP + adenosine
7.4% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + adenosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + cytidine
0.1% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + cytidine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + deoxyadenosine
100% activity
675428
Mycoplasma mycoides
ADP + dAMP
-
-
-
?
2.7.1.76
ATP + deoxycytosine
81% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + dCMP
-
-
-
?
2.7.1.76
ATP + deoxyguanosine
97% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + dGMP
-
-
-
?
2.7.1.76
ATP + deoxyinosine
116% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + dIMP
-
-
-
?
2.7.1.76
ATP + deoxyuridine
0.9% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + dUMP
-
-
-
?
2.7.1.76
ATP + guanosine
5.5% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + GMP
-
-
-
?
2.7.1.76
ATP + guanosine
5.5% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + guanosine 5'-monophosphate
-
-
-
?
2.7.1.76
ATP + inosine
5.9% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + IMP
-
-
-
?
2.7.1.76
ATP + inosine
5.9% of the activity with 2'-deoxyadenosine
675428
Mycoplasma mycoides
ADP + inosine monophosphate
-
-
-
?
2.7.1.76
ATP + penciclovir
1.4% relative activity compared to deoxyadenosine
675428
Mycoplasma mycoides
ADP + ?
-
-
-
?
2.7.1.76
CTP + deoxyadenosine
57% activity compared to ATP
675428
Mycoplasma mycoides
CDP + dAMP
-
-
-
?
2.7.1.76
dATP + deoxyadenosine
2% activity compared to ATP
675428
Mycoplasma mycoides
dADP + dAMP
-
-
-
?
2.7.1.76
dCTP + deoxyadenosine
106% activity compared to ATP
675428
Mycoplasma mycoides
dCDP + dAMP
-
-
-
?
2.7.1.76
dTTP + deoxyadenosine
44% activity compared to ATP
675428
Mycoplasma mycoides
dTDP + dAMP
-
-
-
?
2.7.1.76
additional information
less than 1% activity with dGTP, deoxyuridine, deoxythymidine, 1-beta-D-arabinofuranosyl uracil, 2',3'-dideoxyguanosine, 2',3'-dideoxycytidine, cytidine, acyclovir, ganciclovir, 2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil, and 5-fluoro-2'-deoxyuridine
675428
Mycoplasma mycoides
?
-
-
-
-
2.7.1.76
UTP + deoxyadenosine
22% activity compared to ATP
675428
Mycoplasma mycoides
UDP + dAMP
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.7.1.76
dimer
2 * 25000, Superdex 75 column gel filtration
Mycoplasma mycoides