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Literature summary extracted from

  • Nadeau, O.W.; Anderson, D.W.; Yang, Q.; Artigues, A.; Paschall, J.E.; Wyckoff, G.J.; McClintock, J.L.; Carlson, G.M.
    Evidence for the location of the allosteric activation switch in the multisubunit phosphorylase kinase complex from mass spectrometric identification of chemically crosslinked peptides (2007), J. Mol. Biol., 365, 1429-1445.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.19 additional information location of an allosteric activation switch in the multisubunit phosphorylase kinase complex, overview Oryctolagus cuniculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.19 two-hybrid plasmid construction of fusions containing the PhK beta subunit and its deletion mutants and expression in a yeast two-hybrid system Oryctolagus cuniculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.19 additional information construction of PhKbeta subunit deletion mutants Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Ca2+
-
 Oryctolagus cuniculus
2.7.11.19 Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.19 ATP + glycogen phosphorylase b Oryctolagus cuniculus
-
 ADP + phosphorylated glycogen phosphorylase b
-
 ?
2.7.11.19 additional information Oryctolagus cuniculus the enzyme complex regulates glycogenolysis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.19 Oryctolagus cuniculus
-
 New Zealand white rabbits
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.19 phosphoprotein subunit PhKalpha is autophosphorylated Oryctolagus cuniculus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.19 native enzyme from psoas muscle Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.19 psoas
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.19 ATP + glycogen phosphorylase b
-
 Oryctolagus cuniculus ADP + phosphorylated glycogen phosphorylase b
-
 ?
2.7.11.19 ATP + glycogen S peptide synthetic peptide corresponding to residues 5-18 of its convertible region Oryctolagus cuniculus ADP + phosphorylated glycogen S peptide
-
 ?
2.7.11.19 additional information the enzyme complex regulates glycogenolysis Oryctolagus cuniculus ?
-
 ?
2.7.11.19 additional information subunit PhKalpha is autophosphorylated Oryctolagus cuniculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.19 tetramer the enzyme forms a (alphabetagammadelta)4 complex, location of an allosteric activation switch in the multisubunit phosphorylase kinase complex, overview Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.19 PhK
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.19 30
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.19 6.8
-
 assay at, substrate glycogen phosphorylase b Oryctolagus cuniculus
2.7.11.19 8.3
-
 assay at, substrate glycogen S peptide Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.19 ATP
-
 Oryctolagus cuniculus