EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.60 | additional information | the enzyme is absolutely dependent on the Rab escort protein, REP, cloning and expression of His-tagged REP in Escherichia coli, and purification, overview, recombinant Arabidopsis thaliana REP-6His stimulates Rab geranylgeranylation activity in plant but not yeast cell extracts, overview | Arabidopsis thaliana |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.5.1.60 | additional information | recombinant Arabidopsis thaliana REP interacts with yeast 6His-Ypt1, tobacco 6His-RabA1a, and Arabidopsis RabA2a in vitro preferring the GDP-bound form of the latter | Arabidopsis thaliana |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.5.1.60 | cytoplasm | - |
Arabidopsis thaliana | 5737 | - |
2.5.1.60 | additional information | subcellular localization study, overview | Arabidopsis thaliana | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.60 | geranylgeranyl diphosphate + Rab protein | Arabidopsis thaliana | intracellular vesicular trafficking is regulated by Rab proteins, small GTPases that require posttranslational geranylgeranylation for biological activity, which is catalyzed by the enzyme, a Rab geranylgeranyl transferase in complex with the Rab escort protein, REP, overview | S-geranylgeranyl-Rab protein + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.60 | Arabidopsis thaliana | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.5.1.60 | seedling | - |
Arabidopsis thaliana | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.60 | geranylgeranyl diphosphate + Rab protein | intracellular vesicular trafficking is regulated by Rab proteins, small GTPases that require posttranslational geranylgeranylation for biological activity, which is catalyzed by the enzyme, a Rab geranylgeranyl transferase in complex with the Rab escort protein, REP, overview | Arabidopsis thaliana | S-geranylgeranyl-Rab protein + diphosphate | - |
? | |
2.5.1.60 | geranylgeranyl diphosphate + Rab protein | with recombinantly expressed His6-tagged Saccharomyces cerevisiae Rab GTPase Ypt1 and Nicotiana tabacum NtaRabA1a in vitro substrates, overview | Arabidopsis thaliana | S-geranylgeranyl-Rab protein + diphosphate | - |
? | |
2.5.1.60 | additional information | the enzyme is complexed with the Rab escort protein, REP, recombinant Arabidopsis thaliana REP interacts with yeast 6His-Ypt1, tobacco 6His-RabA1a, and Arabidopsis RabA2a in vitro preferring the GDP-bound form of the latter, overview, enzyme activity with different REPs, wild-type and mutant REPs, and involved REP residues, overview | Arabidopsis thaliana | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.60 | Rab geranylgeranyl transferase | - |
Arabidopsis thaliana |
2.5.1.60 | RabGGTase | - |
Arabidopsis thaliana |