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Literature summary extracted from

  • Bichlmaier, I.; Kurkela, M.; Joshi, T.; Siiskonen, A.; Rueffer, T.; Lang, H.; Suchanova, B.; Vahermo, M.; Finel, M.; Yli-Kauhaluoma, J.
    Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives (2007), J. Med. Chem., 50, 2655-2664.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 (1R)-1-cyclopropyl-2-methylpropan-1-ol IC50: 0.0004 mM Homo sapiens
2.4.1.17 (1R)-1-cyclopropylbut-3-en-1-ol IC50: 0.0004 mM; IC50: 0.0009 mM Homo sapiens
2.4.1.17 (1R)-1-cyclopropylbut-3-ene-1,3-diol IC50: 0.0004 mM Homo sapiens
2.4.1.17 (1R)-1-cyclopropylethanol IC50: 0.0005 mM Homo sapiens
2.4.1.17 (1R)-1-cyclopropylprop-2-en-1-ol IC50: 0.0003 mM Homo sapiens
2.4.1.17 (1R)-1-cyclopropylpropan-1-ol IC50: 0.0002 mM Homo sapiens
2.4.1.17 (1R)-1-cyclopropylpropane-1,3-diol IC50: 0.0002 mM Homo sapiens
2.4.1.17 (1R)-2-chloro-1-cyclopropylethanol IC50: 0.0002 mM Homo sapiens
2.4.1.17 (1S)-1-cyclopropyl-2,2-dimethylpropan-1-ol IC50: 0.0002 mM Homo sapiens
2.4.1.17 (1S)-1-cyclopropyl-2-methylpropan-1-ol IC50: 0.0004 mM Homo sapiens
2.4.1.17 (1S)-1-cyclopropylbut-3-en-1-ol IC50: 0.0002 mM Homo sapiens
2.4.1.17 (1S)-1-cyclopropylethanol IC50: 0.0007 mM Homo sapiens
2.4.1.17 (1S)-1-cyclopropylprop-2-en-1-ol IC50: 0.0006 mM Homo sapiens
2.4.1.17 (1S)-1-cyclopropylpropan-1-ol IC50: 0.0005 mM Homo sapiens
2.4.1.17 (1S)-1-cyclopropylpropane-1,3-diol IC50: 0.0003 mM Homo sapiens
2.4.1.17 (2-cyclopropylethyl)phosphonic acid IC50: 0.012 mM Homo sapiens
2.4.1.17 (2E)-3-cyclopropylacrylic acid IC50: 0.003 mM Homo sapiens
2.4.1.17 (2E)-3-cyclopropylprop-2-en-1-ol IC50: 0.0008 mM Homo sapiens
2.4.1.17 (2Z)-3-cyclopropylacrylic acid IC50: 0.003 mM Homo sapiens
2.4.1.17 (2Z)-3-cyclopropylprop-2-en-1-ol IC50: 0.0007 mM Homo sapiens
2.4.1.17 (3-cyclopropylpropyl)phosphonic acid IC50: 0.032 mM Homo sapiens
2.4.1.17 (3S)-3-cyclopropyl-3-hydroxypropanoic acid IC50: 0.001 mM Homo sapiens
2.4.1.17 (R)-chloro(cyclopropyl)methanol IC50: 0.0002 mM Homo sapiens
2.4.1.17 (R)-cyclopropyl(phenyl)methanol IC50: 0.00007 mM Homo sapiens
2.4.1.17 (S)-cyclopropyl(phenyl)methanol IC50: 0.0009 mM Homo sapiens
2.4.1.17 1-cyclopropyl-2,2-dimethylpropan-1-ol IC50: 0.0008 mM Homo sapiens
2.4.1.17 2-cyclopropyl-N,N-dimethylethanamine IC50: 0.005 mM Homo sapiens
2.4.1.17 2-cyclopropylethanol IC50: 0.0005 mM Homo sapiens
2.4.1.17 3-cyclopropylpropan-1-ol IC50: 0.0009 mM Homo sapiens
2.4.1.17 3-cyclopropylpropanoic acid IC50: 0.002 mM Homo sapiens
2.4.1.17 4-cyclopropylbutan-1-ol IC50: 0.003 mM Homo sapiens
2.4.1.17 4-cyclopropylbutanoic acid IC50: 0.016 mM Homo sapiens
2.4.1.17 cyclopropanecarboxylic acid IC50: 0.001 mM Homo sapiens
2.4.1.17 diethyl [(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonate IC50: 0.01 mM Homo sapiens
2.4.1.17 diethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate IC50: 0.005 mM Homo sapiens
2.4.1.17 diethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate IC50: 0.004 mM Homo sapiens
2.4.1.17 diethyl [(R)-cyclopropyl(hydroxy)methyl]phosphonate IC50: 0.01 mM Homo sapiens
2.4.1.17 dimethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate IC50: 0.003 mM Homo sapiens
2.4.1.17 dimethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate IC50: 0.004 mM Homo sapiens
2.4.1.17 ethyl (3S)-3-cyclopropyl-3-hydroxypropanoate IC50: 0.0003 mM Homo sapiens
2.4.1.17 isolongifolol IC50: 0.0001 mM Homo sapiens
2.4.1.17 [(1E)-3-cyclopropylprop-1-en-1-yl]phosphonic acid IC50: 0.041 mM Homo sapiens
2.4.1.17 [(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonic acid IC50: 0.013 mM Homo sapiens
2.4.1.17 [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid IC50: 0.028 mM Homo sapiens
2.4.1.17 [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid IC50: 0.018 mM Homo sapiens
2.4.1.17 [(E)-2-cyclopropylvinyl]phosphonic acid IC50: 0.008 mM Homo sapiens
2.4.1.17 [(R)-cyclopropyl(hydroxy)methyl]phosphonic acid IC50: 0.018 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P16662
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 1-hydroxy[a]pyrene + UDP-glucuronate
-
 Homo sapiens UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide
-
 ?
2.4.1.17 1-naphthol + UDP-glucuronate
-
 Homo sapiens UDP + naphth-1-yl-beta-D-glucuronide
-
 ?
2.4.1.17 4-methylumbelliferone + UDP-glucuronate
-
 Homo sapiens UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
 ?
2.4.1.17 4-nitrophenol + UDP-glucuronate
-
 Homo sapiens 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?
2.4.1.17 epitestosterone + UDP-glucuronate
-
 Homo sapiens UDP + epitestosterone 17-O-glucuronide
-
 ?
2.4.1.17 scopoletin + UDP-glucuronate
-
 Homo sapiens UDP + scopoletin O-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase 2B7
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.17 0.00007
-
 IC50: 0.00007 mM Homo sapiens (R)-cyclopropyl(phenyl)methanol
2.4.1.17 0.0001
-
 IC50: 0.0001 mM Homo sapiens isolongifolol
2.4.1.17 0.0002
-
 IC50: 0.0002 mM Homo sapiens (1R)-1-cyclopropylpropane-1,3-diol
2.4.1.17 0.0002
-
 IC50: 0.0002 mM Homo sapiens (R)-chloro(cyclopropyl)methanol
2.4.1.17 0.0002
-
 IC50: 0.0002 mM Homo sapiens (1R)-2-chloro-1-cyclopropylethanol
2.4.1.17 0.0002
-
 IC50: 0.0002 mM Homo sapiens (1R)-1-cyclopropylpropan-1-ol
2.4.1.17 0.0002
-
 IC50: 0.0002 mM Homo sapiens (1S)-1-cyclopropylbut-3-en-1-ol
2.4.1.17 0.0002
-
 IC50: 0.0002 mM Homo sapiens (1S)-1-cyclopropyl-2,2-dimethylpropan-1-ol
2.4.1.17 0.0003
-
 IC50: 0.0003 mM Homo sapiens ethyl (3S)-3-cyclopropyl-3-hydroxypropanoate
2.4.1.17 0.0003
-
 IC50: 0.0003 mM Homo sapiens (1S)-1-cyclopropylpropane-1,3-diol
2.4.1.17 0.0003
-
 IC50: 0.0003 mM Homo sapiens (1R)-1-cyclopropylprop-2-en-1-ol
2.4.1.17 0.0004
-
 IC50: 0.0004 mM Homo sapiens (1R)-1-cyclopropylbut-3-en-1-ol
2.4.1.17 0.0004
-
 IC50: 0.0004 mM Homo sapiens (1R)-1-cyclopropylbut-3-ene-1,3-diol
2.4.1.17 0.0004
-
 IC50: 0.0004 mM Homo sapiens (1R)-1-cyclopropyl-2-methylpropan-1-ol
2.4.1.17 0.0004
-
 IC50: 0.0004 mM Homo sapiens (1S)-1-cyclopropyl-2-methylpropan-1-ol
2.4.1.17 0.0005
-
 IC50: 0.0005 mM Homo sapiens 2-cyclopropylethanol
2.4.1.17 0.0005
-
 IC50: 0.0005 mM Homo sapiens (1R)-1-cyclopropylethanol
2.4.1.17 0.0005
-
 IC50: 0.0005 mM Homo sapiens (1S)-1-cyclopropylpropan-1-ol
2.4.1.17 0.0006
-
 IC50: 0.0006 mM Homo sapiens (1S)-1-cyclopropylprop-2-en-1-ol
2.4.1.17 0.0007
-
 IC50: 0.0007 mM Homo sapiens (2Z)-3-cyclopropylprop-2-en-1-ol
2.4.1.17 0.0007
-
 IC50: 0.0007 mM Homo sapiens (1S)-1-cyclopropylethanol
2.4.1.17 0.0008
-
 IC50: 0.0008 mM Homo sapiens (2E)-3-cyclopropylprop-2-en-1-ol
2.4.1.17 0.0008
-
 IC50: 0.0008 mM Homo sapiens 1-cyclopropyl-2,2-dimethylpropan-1-ol
2.4.1.17 0.0009
-
 IC50: 0.0009 mM Homo sapiens (1R)-1-cyclopropylbut-3-en-1-ol
2.4.1.17 0.0009
-
 IC50: 0.0009 mM Homo sapiens 3-cyclopropylpropan-1-ol
2.4.1.17 0.0009
-
 IC50: 0.0009 mM Homo sapiens (S)-cyclopropyl(phenyl)methanol
2.4.1.17 0.001
-
 IC50: 0.001 mM Homo sapiens cyclopropanecarboxylic acid
2.4.1.17 0.001
-
 IC50: 0.001 mM Homo sapiens (3S)-3-cyclopropyl-3-hydroxypropanoic acid
2.4.1.17 0.002
-
 IC50: 0.002 mM Homo sapiens 3-cyclopropylpropanoic acid
2.4.1.17 0.003
-
 IC50: 0.003 mM Homo sapiens 4-cyclopropylbutan-1-ol
2.4.1.17 0.003
-
 IC50: 0.003 mM Homo sapiens (2E)-3-cyclopropylacrylic acid
2.4.1.17 0.003
-
 IC50: 0.003 mM Homo sapiens (2Z)-3-cyclopropylacrylic acid
2.4.1.17 0.003
-
 IC50: 0.003 mM Homo sapiens dimethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate
2.4.1.17 0.004
-
 IC50: 0.004 mM Homo sapiens dimethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate
2.4.1.17 0.004
-
 IC50: 0.004 mM Homo sapiens diethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate
2.4.1.17 0.005
-
 IC50: 0.005 mM Homo sapiens 2-cyclopropyl-N,N-dimethylethanamine
2.4.1.17 0.005
-
 IC50: 0.005 mM Homo sapiens diethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate
2.4.1.17 0.008
-
 IC50: 0.008 mM Homo sapiens [(E)-2-cyclopropylvinyl]phosphonic acid
2.4.1.17 0.01
-
 IC50: 0.01 mM Homo sapiens diethyl [(R)-cyclopropyl(hydroxy)methyl]phosphonate
2.4.1.17 0.01
-
 IC50: 0.01 mM Homo sapiens diethyl [(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonate
2.4.1.17 0.012
-
 IC50: 0.012 mM Homo sapiens (2-cyclopropylethyl)phosphonic acid
2.4.1.17 0.013
-
 IC50: 0.013 mM Homo sapiens [(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonic acid
2.4.1.17 0.016
-
 IC50: 0.016 mM Homo sapiens 4-cyclopropylbutanoic acid
2.4.1.17 0.018
-
 IC50: 0.018 mM Homo sapiens [(R)-cyclopropyl(hydroxy)methyl]phosphonic acid
2.4.1.17 0.018
-
 IC50: 0.018 mM Homo sapiens [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid
2.4.1.17 0.028
-
 IC50: 0.028 mM Homo sapiens [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid
2.4.1.17 0.032
-
 IC50: 0.032 mM Homo sapiens (3-cyclopropylpropyl)phosphonic acid
2.4.1.17 0.041
-
 IC50: 0.041 mM Homo sapiens [(1E)-3-cyclopropylprop-1-en-1-yl]phosphonic acid