Literature summary extracted from

Gao, F.; Yan, X.; Shakya, T.; Baettig, O.M.; Ait-Mohand-Brunet, S.; Berghuis, A.M.; Wright, G.D.; Auclair, K.
Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6-N-acetyltransferases (2006), J. Med. Chem., 49, 5273-5281.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.82	CoA-aminoglycoside 1a	-	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 1b	-	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 1c	-	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 1d	-	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 2	-	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 3	-	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 4a	competitive	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 4b	competitive	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 4c	competitive	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 4d	competitive	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 4e	competitive	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 4f	competitive	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 5b	competitive	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 5d	competitive	Enterococcus faecium
2.3.1.82	CoA-aminoglycoside 5e	competitive	Enterococcus faecium

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.82	Enterococcus faecium	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.82	acetyl-CoA + neamine	-	Enterococcus faecium	CoA + 6'-N-acetylneamine	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.3.1.82	0.000043	-	CoA-aminoglycoside 1b	-	Enterococcus faecium
2.3.1.82	0.000076	-	CoA-aminoglycoside 1a	-	Enterococcus faecium
2.3.1.82	0.00011	-	CoA-aminoglycoside 2	-	Enterococcus faecium
2.3.1.82	0.000119	-	CoA-aminoglycoside 3	-	Enterococcus faecium
2.3.1.82	0.000161	-	CoA-aminoglycoside 1c	-	Enterococcus faecium
2.3.1.82	0.0012	-	CoA-aminoglycoside 4c	-	Enterococcus faecium
2.3.1.82	0.0022	-	CoA-aminoglycoside 5d	-	Enterococcus faecium
2.3.1.82	0.0034	-	CoA-aminoglycoside 4a	-	Enterococcus faecium
2.3.1.82	0.0034	-	CoA-aminoglycoside 4d	-	Enterococcus faecium
2.3.1.82	0.0036	-	CoA-aminoglycoside 4e	-	Enterococcus faecium
2.3.1.82	0.0074	-	CoA-aminoglycoside 4f	-	Enterococcus faecium
2.3.1.82	0.008	-	CoA-aminoglycoside 1d	-	Enterococcus faecium
2.3.1.82	0.011	-	CoA-aminoglycoside 5e	-	Enterococcus faecium
2.3.1.82	0.012	-	CoA-aminoglycoside 5b	-	Enterococcus faecium
2.3.1.82	0.13	-	CoA-aminoglycoside 4b	-	Enterococcus faecium

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Release 2023.1 (January 2023)