EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.1 | (Z)-2-(4-hydroxybenzylidene)-4-hydroxybenzofuran-3(2H)-one | 71% inhibition at 0.1 mM | Homo sapiens | |
1.14.18.1 | (Z)-2-(4-hydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one | 69% inhibition at 0.1 mM | Homo sapiens | |
1.14.18.1 | (Z)-2-(4-hydroxybenzylidene)benzofuran-3(2H)-one | 39% inhibition at 0.1 mM | Homo sapiens | |
1.14.18.1 | (Z)-4,6-dihydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2H)-one | - |
Homo sapiens | |
1.14.18.1 | (Z)-4,6-dihydroxy-2-(4-methoxybenzylidene)benzofuran-3(2H)-one | 11% inhibition at 0.1 mM | Homo sapiens | |
1.14.18.1 | 4,6,4'-trihydroxyaurone | 75% inhibition at 0.1 mM | Homo sapiens | |
1.14.18.1 | arbutin | - |
Homo sapiens | |
1.14.18.1 | benzylidenebenzofuran-3(2H)-one | - |
Homo sapiens | |
1.14.18.1 | flavone | - |
Homo sapiens | |
1.14.18.1 | kojic acid | 20% inhibition at 7 mM | Homo sapiens | |
1.14.18.1 | additional information | inhibitory potency of different aurones, no inhibition by apigenin, (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one, (Z)-2-(4-ethylbenzylidene)-6-hydroxybenzofuran-3(2H)-one, (Z)-benzylidene-4,6-dihydroxybenzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(4-ethylbenzylidene)benzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(2-ethylbenzylidene)benzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(2-hydroxybenzylidene)benzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(4-ethyloxybenzylidene)benzofuran-3(2H)-one, (Z)-2-(4-tert-butylbenzylidene)-4,6-dihydroxybenzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(4-propylbenzylidene)benzofuran-3(2H)-one, and (Z)-4,6-dihydroxy-2-(4-hydroxy-3-methoxybenzylidene)benzofuran-3(2H)-one, overview, cytotoxic effects on melanocytes depend on the skin color type of the origin, overview | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.1 | Cu2+ | copper-containing enzyme | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | L-tyrosine + L-dopa + O2 | Homo sapiens | - |
L-dopa + dopaquinone + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.18.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.18.1 | melanocyte | from subjects of different skin color, overview | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | L-tyrosine + L-dopa + O2 | - |
Homo sapiens | L-dopa + dopaquinone + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.18.1 | tyrosinase | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.18.1 | 0.0317 | - |
(Z)-2-(4-hydroxybenzylidene)-4-hydroxybenzofuran-3(2H)-one | - |
Homo sapiens | |
1.14.18.1 | 0.038 | - |
(Z)-4,6-dihydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2H)-one | - |
Homo sapiens | |
1.14.18.1 | 0.0384 | - |
(Z)-2-(4-hydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one | - |
Homo sapiens |