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Literature summary extracted from

  • Baumgartner, R.; Walloschek, M.; Kralik, M.; Gotschlich, A.; Tasler, S.; Mies, J.; Leban, J.
    Dual binding mode of a novel series of DHODH inhibitors (2006), J. Med. Chem., 49, 1239-1247.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.5.2 medicine development of small molecule inhibitors against DHODH Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.5.2 in complex with low molecular weight compounds that inhibit the enzyme in the nanomolar range, by hanging-drop vapor diffusion method, to 2.15 A resolution Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.2 additional information competitive nature of small molecule inhibitors toward the putative ubiquinone binding site Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.2 Homo sapiens Q02127
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.5.2
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.2 dihydroorotate + 2,6-dichlorophenolindophenol
-
 Homo sapiens orotate + reduced 2,6-dichlorophenolindophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.5.2 DHODH
-
 Homo sapiens