Literature summary extracted from

AbuKhader, M.; Heap, J.; De Matteis, C.; Kellam, B.; Doughty, S.W.; Minton, N.; Paoli, M.
Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex (2005), J. Med. Chem., 48, 7714-7719.

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
1.6.5.2	in complex with anticancer prodrug CB1954	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.5.2	Homo sapiens	-	isoform NQO2	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.6.5.2	5-aziridin-1-yl-2,4-dinitrobenzamide + NAD(P)H + H+	i.e. CB1954, anticancer prodrug	Homo sapiens	5-aziridin-1-yl-4-(hydroxyamino)-2-nitrobenzamide	-	?

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Release 2023.1 (January 2023)