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Literature summary extracted from

  • Chimenti, F.; Maccioni, E.; Secci, D.; Bolasco, A.; Chimenti, P.; Granese, A.; Befani, O.; Turini, P.; Alcaro, S.; Ortuso, F.; Cirilli, R.; La Torre, F.; Cardia, M.C.; Distinto, S.
    Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole derivatives (2005), J. Med. Chem., 48, 7113-7122.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
1.4.3.4 5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Bos taurus P21398
-
-
1.4.3.4 Bos taurus P56560
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Bos taurus
1.4.3.4 MAO-B
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.0000015
-
 5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.000004
-
 5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.000006
-
 3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.000006
-
 5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.000006
-
 5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.000007
-
 3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.000008
-
 3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.00001
-
 3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.00001
-
 5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.00002
-
 5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.000027
-
 3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.000031
-
 5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.000041
-
 5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.00005
-
 5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.00005
-
 5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
1.4.3.4 0.00005
-
 3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.00005
-
 3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.00017
-
 5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.00037
-
 3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
1.4.3.4 0.001
-
 5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus