EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.58 | ABT-839 | - |
Homo sapiens | |
2.5.1.58 | BMS-214662 | - |
Homo sapiens | |
2.5.1.58 | L-778,123 | - |
Homo sapiens | |
2.5.1.58 | R115777 | - |
Homo sapiens | |
2.5.1.58 | SCH66336 | - |
Homo sapiens | |
2.5.1.59 | L-778,123 | - |
Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.58 | Mg2+ | required, stabilizes the developing negative charge on the diphosphate as the bond breaks between the a-phosphate and the C1 atom of the farnesyl group | Homo sapiens | |
2.5.1.58 | Zn2+ | contains one Zn2+ ion per dimer, required for catalysis and peptide binding | Homo sapiens | |
2.5.1.59 | Zn2+ | required for catalysis and peptide binding, one zinc ion per protein dimer | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.5.1.58 | 46000 | - |
1 * 48000 + 1 * 46000 | Homo sapiens |
2.5.1.58 | 48000 | - |
1 * 48000 + 1 * 46000 | Homo sapiens |
2.5.1.59 | 43000 | - |
1 * 43000 + 1 * 48000 | Rattus norvegicus |
2.5.1.59 | 48000 | - |
1 * 43000 + 1 * 48000 | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.58 | Homo sapiens | - |
- |
- |
2.5.1.59 | Rattus norvegicus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.58 | farnesyl diphosphate + protein-cysteine | - |
Homo sapiens | diphosphate + S-farnesyl protein | - |
ir | |
2.5.1.59 | geranylgeranyl diphosphate + Cys-Val-Leu-Leu | - |
Rattus norvegicus | S-geranylgeranyl-Cys-Val-Leu-Leu + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Cys-Val-Leu-Ser | - |
Rattus norvegicus | S-geranylgeranyl-Cys-Val-Leu-Ser + diphosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.5.1.58 | heterodimer | 1 * 48000 + 1 * 46000 | Homo sapiens |
2.5.1.59 | heterodimer | 1 * 43000 + 1 * 48000 | Rattus norvegicus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.58 | FTase | - |
Homo sapiens |
2.5.1.59 | geranylgeranyltransferase type I | - |
Rattus norvegicus |
2.5.1.59 | GGTase-I | - |
Rattus norvegicus |