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Literature summary extracted from

  • Mirza, R.; Hayasaka, S.; Takagishi, Y.; Kambe, F.; Ohmori, S.; Maki, K.; Yamamoto, M.; Murakami, K.; Kaji, T.; Zadworny, D.; Murata, Y.; Seo, H.
    DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis (2006), J. Invest. Dermatol., 126, 638-647.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.72 medicine DHCR24 plays crucial role for skin development and its proper function Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.72 additional information DHCR24 knockout mice, development of the epidermis, especially keratinization, is impaired, altered expression of filaggrin, loricrin, and involcrin, transepidermal water loss is markedly increased, impaired skin barrier function Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.72 Mus musculus Q8VCH6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.72 epidermis abundantly expressed throughout the epidermis except for the stratum corneum and in hair follicles Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.72 desmosterol + NADPH
-
 Mus musculus cholesterol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.72 3beta-hydroxysterol-delta24 reductase
-
 Mus musculus
1.3.1.72 DHCR24
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 Mus musculus