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Literature summary extracted from
- Nitric oxide dioxygenase function and mechanism of flavohemoglobin, hemoglobin, myoglobin and their associated reductases (2005), J. Inorg. Biochem., 99, 247-266.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.12.17 | clotrimazole | - |
Bacillus subtilis |  |
| 1.14.12.17 | clotrimazole | - |
Cupriavidus necator | |
| 1.14.12.17 | clotrimazole | - |
Deinococcus radiodurans | |
| 1.14.12.17 | clotrimazole | - |
Escherichia coli | |
| 1.14.12.17 | clotrimazole | - |
Klebsiella pneumoniae | |
| 1.14.12.17 | clotrimazole | - |
Pseudomonas aeruginosa | |
| 1.14.12.17 | clotrimazole | - |
Saccharomyces cerevisiae | |
| 1.14.12.17 | clotrimazole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 1.14.12.17 | CO | - |
Bacillus subtilis | |
| 1.14.12.17 | CO | - |
Cupriavidus necator | |
| 1.14.12.17 | CO | - |
Deinococcus radiodurans | |
| 1.14.12.17 | CO | - |
Escherichia coli | |
| 1.14.12.17 | CO | - |
Klebsiella pneumoniae | |
| 1.14.12.17 | CO | - |
Pseudomonas aeruginosa | |
| 1.14.12.17 | CO | - |
Saccharomyces cerevisiae | |
| 1.14.12.17 | CO | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 1.14.12.17 | econazole | - |
Bacillus subtilis | |
| 1.14.12.17 | econazole | - |
Cupriavidus necator | |
| 1.14.12.17 | econazole | - |
Deinococcus radiodurans | |
| 1.14.12.17 | econazole | - |
Escherichia coli | |
| 1.14.12.17 | econazole | - |
Klebsiella pneumoniae | |
| 1.14.12.17 | econazole | - |
Pseudomonas aeruginosa | |
| 1.14.12.17 | econazole | - |
Saccharomyces cerevisiae | |
| 1.14.12.17 | econazole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 1.14.12.17 | ketoconazol | - |
Bacillus subtilis | |
| 1.14.12.17 | ketoconazol | - |
Cupriavidus necator | |
| 1.14.12.17 | ketoconazol | - |
Deinococcus radiodurans | |
| 1.14.12.17 | ketoconazol | - |
Escherichia coli | |
| 1.14.12.17 | ketoconazol | - |
Klebsiella pneumoniae | |
| 1.14.12.17 | ketoconazol | - |
Pseudomonas aeruginosa | |
| 1.14.12.17 | ketoconazol | - |
Saccharomyces cerevisiae | |
| 1.14.12.17 | ketoconazol | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 1.14.12.17 | miconazole | - |
Bacillus subtilis | |
| 1.14.12.17 | miconazole | - |
Cupriavidus necator | |
| 1.14.12.17 | miconazole | - |
Deinococcus radiodurans | |
| 1.14.12.17 | miconazole | - |
Escherichia coli | |
| 1.14.12.17 | miconazole | - |
Klebsiella pneumoniae | |
| 1.14.12.17 | miconazole | - |
Pseudomonas aeruginosa | |
| 1.14.12.17 | miconazole | - |
Saccharomyces cerevisiae | |
| 1.14.12.17 | miconazole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.12.17 | Bacillus subtilis | - |
- |
- |
| 1.14.12.17 | Cupriavidus necator | - |
- |
- |
| 1.14.12.17 | Deinococcus radiodurans | - |
- |
- |
| 1.14.12.17 | Escherichia coli | - |
- |
- |
| 1.14.12.17 | Klebsiella pneumoniae | - |
- |
- |
| 1.14.12.17 | Pseudomonas aeruginosa | - |
- |
- |
| 1.14.12.17 | Saccharomyces cerevisiae | - |
- |
- |
| 1.14.12.17 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.12.17 | NO + O2 + NAD(P)H | - |
Salmonella enterica subsp. enterica serovar Typhimurium | NO3- + NAD(P)+ + H+ | - |
? | |
| 1.14.12.17 | NO + O2 + NAD(P)H | - |
Bacillus subtilis | NO3- + NAD(P)+ + H+ | - |
? | |
| 1.14.12.17 | NO + O2 + NAD(P)H | - |
Escherichia coli | NO3- + NAD(P)+ + H+ | - |
? | |
| 1.14.12.17 | NO + O2 + NAD(P)H | - |
Saccharomyces cerevisiae | NO3- + NAD(P)+ + H+ | - |
? | |
| 1.14.12.17 | NO + O2 + NAD(P)H | - |
Pseudomonas aeruginosa | NO3- + NAD(P)+ + H+ | - |
? | |
| 1.14.12.17 | NO + O2 + NAD(P)H | - |
Klebsiella pneumoniae | NO3- + NAD(P)+ + H+ | - |
? | |
| 1.14.12.17 | NO + O2 + NAD(P)H | - |
Cupriavidus necator | NO3- + NAD(P)+ + H+ | - |
? | |
| 1.14.12.17 | NO + O2 + NAD(P)H | - |
Deinococcus radiodurans | NO3- + NAD(P)+ + H+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.12.17 | flavohemoglobin | flavoHb | Salmonella enterica subsp. enterica serovar Typhimurium |
| 1.14.12.17 | flavohemoglobin | flavoHb | Bacillus subtilis |
| 1.14.12.17 | flavohemoglobin | flavoHb | Escherichia coli |
| 1.14.12.17 | flavohemoglobin | flavoHb | Saccharomyces cerevisiae |
| 1.14.12.17 | flavohemoglobin | flavoHb | Pseudomonas aeruginosa |
| 1.14.12.17 | flavohemoglobin | flavoHb | Klebsiella pneumoniae |
| 1.14.12.17 | flavohemoglobin | flavoHb | Cupriavidus necator |
| 1.14.12.17 | flavohemoglobin | flavoHb | Deinococcus radiodurans |
| 1.14.12.17 | NOD | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| 1.14.12.17 | NOD | - |
Bacillus subtilis |
| 1.14.12.17 | NOD | - |
Escherichia coli |
| 1.14.12.17 | NOD | - |
Saccharomyces cerevisiae |
| 1.14.12.17 | NOD | - |
Pseudomonas aeruginosa |
| 1.14.12.17 | NOD | - |
Klebsiella pneumoniae |
| 1.14.12.17 | NOD | - |
Cupriavidus necator |
| 1.14.12.17 | NOD | - |
Deinococcus radiodurans |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.12.17 | FAD | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 1.14.12.17 | FAD | - |
Bacillus subtilis | |
| 1.14.12.17 | FAD | - |
Escherichia coli | |
| 1.14.12.17 | FAD | - |
Saccharomyces cerevisiae | |
| 1.14.12.17 | FAD | - |
Pseudomonas aeruginosa | |
| 1.14.12.17 | FAD | - |
Klebsiella pneumoniae | |
| 1.14.12.17 | FAD | - |
Cupriavidus necator | |
| 1.14.12.17 | FAD | - |
Deinococcus radiodurans | |
| 1.14.12.17 | NADH | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 1.14.12.17 | NADH | - |
Bacillus subtilis | |
| 1.14.12.17 | NADH | - |
Escherichia coli | |
| 1.14.12.17 | NADH | - |
Saccharomyces cerevisiae | |
| 1.14.12.17 | NADH | - |
Pseudomonas aeruginosa | |
| 1.14.12.17 | NADH | - |
Klebsiella pneumoniae | |
| 1.14.12.17 | NADH | - |
Cupriavidus necator | |
| 1.14.12.17 | NADH | - |
Deinococcus radiodurans | |
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