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Literature summary extracted from

  • Mizrachi Nebenzahl, Y.; Bernstein, A.; Portnoi, M.; Shagan, M.; Rom, S.; Porgador, A.; Dagan, R.
    Streptococcus pneumoniae surface-exposed glutamyl tRNA synthetase, a putative adhesin, is able to induce a partially protective immune response in mice (2007), J. Infect. Dis., 196, 945-953.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.17 gene gltX, DNA and amino acid sequence determination and analysis, expression in Escherichia coli Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.17 additional information rGtS and anti-rGtS antiserum significantly inhibits the adhesion of 3 pairs of encapsulated and unencapsulated strains of Streptococcus pneumoniae to human epithelial A549 cells Streptococcus pneumoniae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.17 cell surface
-
 Streptococcus pneumoniae 9986
-
6.1.1.17 cell wall the enzyme is surface-exposed Streptococcus pneumoniae 5618
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.17 Mg2+
-
 Streptococcus pneumoniae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.1.1.17 58000
-
 x * 58000, recombinant enzyme, SDS-PAGE Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.17 ATP + L-glutamate + tRNAGlu Streptococcus pneumoniae
-
 AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?
6.1.1.17 additional information Streptococcus pneumoniae GtS is an age-dependent Streptococcus pneumoniae antigen and is a surface-located adhesin that is capable of inducing a partially protective immune response against Streptococcus pneumoniae in mice, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.17 Streptococcus pneumoniae
-
 several strains and cultivars, overview, gene gltX
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.17 ATP + L-glutamate + tRNAGlu
-
 Streptococcus pneumoniae AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?
6.1.1.17 additional information GtS is an age-dependent Streptococcus pneumoniae antigen and is a surface-located adhesin that is capable of inducing a partially protective immune response against Streptococcus pneumoniae in mice, overview Streptococcus pneumoniae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.1.17 ? x * 58000, recombinant enzyme, SDS-PAGE Streptococcus pneumoniae

Synonyms

EC Number Synonyms Comment Organism
6.1.1.17 GtS
-
 Streptococcus pneumoniae
6.1.1.17 surface-exposed glutamyl tRNA synthetase
-
 Streptococcus pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.17 ATP
-
 Streptococcus pneumoniae