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Literature summary extracted from

  • Ramirez, B.L.; Howard, O.M.; Dong, H.F.; Edamatsu, T.; Gao, P.; Hartlein, M.; Kron, M.
    Brugia malayi asparaginyl-transfer RNA synthetase induces chemotaxis of human leukocytes and activates G-protein-coupled receptors CXCR1 and CXCR2 (2006), J. Infect. Dis., 193, 1164-1171.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.22 expression in Escherichia coli Brugia malayi
6.1.1.22 expression in Escherichia coli Homo sapiens
6.3.5.6 expression in Escherichia coli Brugia malayi
6.3.5.6 expression in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
6.1.1.22 additional information the recombinant human enzyme does not induce leukocyte chemotaxis of HEK-293T cells transfected with G-protein-coupled receptors CXCR1 or CXCR2, overview Homo sapiens
6.1.1.22 additional information treatment of HEK-293T cells expressing CXCR2 with the filarial AsnRS, recombinantly expressed in Escherichia coli, parasite AsnRS is chemotactic for human neutrophils and eosinophils, blocks CXCL1-induced calcium flux, and induces mitogen-activated protein kinase, overview Brugia malayi
6.3.5.6 additional information the recombinant human enzyme does not induce leukocyte chemotaxis of HEK-293T cells transfected with G-protein-coupled receptors CXCR1 or CXCR2, overview Homo sapiens
6.3.5.6 additional information treatment of HEK-293T cells expressing CXCR2 with the filarial AsnRS, recombinantly expressed in Escherichia coli, parasite AsnRS is chemotactic for human neutrophils and eosinophils, blocks CXCL1-induced calcium flux, and induces mitogen-activated protein kinase, overview Brugia malayi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.22 cytoplasm
-
 Homo sapiens 5737
-
6.3.5.6 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.22 additional information Homo sapiens human cytoplasmic aminoacyl-tRNA synthetases, which are autoantigens in idiopathic inflammatory myopathies, activate chemokine receptors on T lymphocytes, monocytes, and immature dendritic cells by recruiting immune cells that could induce innate and adaptive immune responses ?
-
 ?
6.1.1.22 additional information Brugia malayi the parasite Brugia malayi enzyme, in analogy to the human enzyme, induces human leukocyte chemotaxis and activates G-protein-coupled receptors CXCR1 and CXCR2, but not CXCR3, filarial asparaginyl-tRNA synthetase, AsnRS, is known to be an immunodominant antigen that induces strong human immunoglobulin G3 responses and contributes to the development of chronic inflammatory disease such as lymphatic filariasis, overview ?
-
 ?
6.3.5.6 additional information Homo sapiens human cytoplasmic aminoacyl-tRNA synthetases, which are autoantigens in idiopathic inflammatory myopathies, activate chemokine receptors on T lymphocytes, monocytes, and immature dendritic cells by recruiting immune cells that could induce innate and adaptive immune responses ?
-
 ?
6.3.5.6 additional information Brugia malayi the parasite Brugia malayi enzyme, in analogy to the human enzyme, induces human leukocyte chemotaxis and activates G-protein-coupled receptors CXCR1 and CXCR2, but not CXCR3, filarial asparaginyl-tRNA synthetase, AsnRS, is known to be an immunodominant antigen that induces strong human immunoglobulin G3 responses and contributes to the development of chronic inflammatory disease such as lymphatic filariasis, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.22 Brugia malayi
-
 human nematode parasite
-
6.1.1.22 Homo sapiens
-
-
-
6.3.5.6 Brugia malayi
-
 human nematode parasite
-
6.3.5.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.22 HEK-293T cell
-
 Homo sapiens
-
6.1.1.22 leukocyte primary Homo sapiens
-
6.1.1.22 T-lymphocyte
-
 Homo sapiens
-
6.3.5.6 HEK-293T cell
-
 Homo sapiens
-
6.3.5.6 leukocyte primary Homo sapiens
-
6.3.5.6 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.22 additional information human cytoplasmic aminoacyl-tRNA synthetases, which are autoantigens in idiopathic inflammatory myopathies, activate chemokine receptors on T lymphocytes, monocytes, and immature dendritic cells by recruiting immune cells that could induce innate and adaptive immune responses Homo sapiens ?
-
 ?
6.1.1.22 additional information the parasite Brugia malayi enzyme, in analogy to the human enzyme, induces human leukocyte chemotaxis and activates G-protein-coupled receptors CXCR1 and CXCR2, but not CXCR3, filarial asparaginyl-tRNA synthetase, AsnRS, is known to be an immunodominant antigen that induces strong human immunoglobulin G3 responses and contributes to the development of chronic inflammatory disease such as lymphatic filariasis, overview Brugia malayi ?
-
 ?
6.3.5.6 additional information human cytoplasmic aminoacyl-tRNA synthetases, which are autoantigens in idiopathic inflammatory myopathies, activate chemokine receptors on T lymphocytes, monocytes, and immature dendritic cells by recruiting immune cells that could induce innate and adaptive immune responses Homo sapiens ?
-
 ?
6.3.5.6 additional information the parasite Brugia malayi enzyme, in analogy to the human enzyme, induces human leukocyte chemotaxis and activates G-protein-coupled receptors CXCR1 and CXCR2, but not CXCR3, filarial asparaginyl-tRNA synthetase, AsnRS, is known to be an immunodominant antigen that induces strong human immunoglobulin G3 responses and contributes to the development of chronic inflammatory disease such as lymphatic filariasis, overview Brugia malayi ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.22 AsnRS
-
 Brugia malayi
6.1.1.22 AsnRS
-
 Homo sapiens
6.1.1.22 asparaginyl-transfer RNA synthetase
-
 Brugia malayi
6.1.1.22 asparaginyl-transfer RNA synthetase
-
 Homo sapiens
6.1.1.22 Asparaginyl-tRNA synthetase
-
 Brugia malayi
6.1.1.22 Asparaginyl-tRNA synthetase
-
 Homo sapiens
6.3.5.6 AsnRS
-
 Brugia malayi
6.3.5.6 AsnRS
-
 Homo sapiens
6.3.5.6 asparaginyl-transfer RNA synthetase
-
 Brugia malayi
6.3.5.6 asparaginyl-transfer RNA synthetase
-
 Homo sapiens
6.3.5.6 Asparaginyl-tRNA synthetase
-
 Brugia malayi
6.3.5.6 Asparaginyl-tRNA synthetase
-
 Homo sapiens