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Literature summary extracted from

  • Alvarez-Arias, D.A.; Campbell, K.S.
    Protein kinase C regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells (2007), J. Immunol., 179, 5281-5290.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 1,2-diacyl-sn-glycerol
-
 Homo sapiens
2.7.11.13 12-O-Tetradecanoylphorbol 13-acetate
-
 Homo sapiens
2.7.11.13 phosphatidylserine
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.13 Ca2+ activates Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.13 ATP + inhibitory killer cell Ig-like receptor Homo sapiens the enzyme regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells, KIR negatively regulate NK cell cytotoxicity by activating Src homology 2 domain-containing protein tyrsine phospatase 1 and 2, overview ADP + phosphorylated inhibitory killer cell Ig-like receptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.13 NK-92 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 ATP + inhibitory killer cell Ig-like receptor the enzyme regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells, KIR negatively regulate NK cell cytotoxicity by activating Src homology 2 domain-containing protein tyrsine phospatase 1 and 2, overview Homo sapiens ADP + phosphorylated inhibitory killer cell Ig-like receptor
-
 ?
2.7.11.13 ATP + inhibitory killer cell Ig-like receptor phosphorylation of the cytoplasmic tail, mutational analysis of kinase phosphorylation sites, e.g. Ser394, activity with substrate mutants, overview Homo sapiens ADP + phosphorylated inhibitory killer cell Ig-like receptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKC
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.13 30
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.13 ATP
-
 Homo sapiens