Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nanamori, M.; Chen, J.; Du, X.; Ye, R.D.
    Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells (2007), J. Immunol., 178, 416-427.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 8-bromo-cGMP
-
 Rattus norvegicus
2.7.11.12 cGMP
-
 Rattus norvegicus
2.7.11.12 formyl-methionyl-leucyl-phenylalanine
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 KT5823 in vivo inhibition in leukemia cells causes reduced agonist-stimulated beta-hexosaminidase release and abolishes vesicular fusion with the plasma membrane Rattus norvegicus
2.7.11.12 Rp-8-Br-cGMP in vivo inhibition in leukemia cells causes reduced agonist-stimulated beta-hexosaminidase release and abolishes vesicular fusion with the plasma membrane Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.12 ATP + target membrane SNARe complex Rattus norvegicus the enzyme is involved in regulation of degranulation of leukocytes by phosphorylation of target membrane SNARe complex together with the phosphoinositide 3-kinase ADP + phosphorylated target membrane SNARe complex
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 leukemia cell
-
 Rattus norvegicus
-
2.7.11.12 leukocyte
-
 Rattus norvegicus
-
2.7.11.12 mast cell
-
 Rattus norvegicus
-
2.7.11.12 RBL-2H3 cell a basophilic leukemia cell line Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 ATP + target membrane SNARe complex the enzyme is involved in regulation of degranulation of leukocytes by phosphorylation of target membrane SNARe complex together with the phosphoinositide 3-kinase Rattus norvegicus ADP + phosphorylated target membrane SNARe complex
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 PKG
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.12 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.12 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.12 ATP
-
 Rattus norvegicus