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Literature summary extracted from

  • Wissmann, G.; Alvarez-Martinez, M.J.; Meshnick, S.R.; Dihel, A.R.; Prolla, J.C.
    Absence of dihydropteroate synthase mutations in Pneumocystis jirovecii from Brazilian AIDS patients (2006), J. Eukaryot. Microbiol., 53, 305-307.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 trimethoprim-sulfamethoxazole
-
 Pneumocystis jirovecii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Pneumocystis jirovecii
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Pneumocystis jirovecii Q9UUP4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.15 additional information bronchoalveolar lavage isolates from AIDS patient in Brazil Pneumocystis jirovecii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
 Pneumocystis jirovecii diphosphate + 7,8-dihydropteroate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 7,8-dihydropteroate synthase
-
 Pneumocystis jirovecii
2.5.1.15 DHPS
-
 Pneumocystis jirovecii
2.5.1.15 dihydropteroate synthetase
-
 Pneumocystis jirovecii