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Literature summary extracted from

  • Wang, Y.; Zhang, S.Y.; Ma, X.F.; Tian, W.X.
    Potent inhibition of fatty acid synthase by parasitic loranthus [Taxillus chinensis (dc.) danser] and its constituent avicularin (2006), J. Enzyme Inhib. Med. Chem., 21, 87-93.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.85 avicularin IC50: 0.00615 mM Anas platyrhynchos
2.3.1.85 hyperoside IC50: 0.0746 mM Anas platyrhynchos
2.3.1.85 isoquercitrin IC50: 0.108 mM Anas platyrhynchos
2.3.1.85 additional information FAS is potently inhibited by extracts of Taxillus chinensis Danser. Potent, reversible and a fast irreversible inhibition. IC50: 480 ng/ml Anas platyrhynchos
2.3.1.85 quercitrin IC50: 0.0456 mM Anas platyrhynchos

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.85 Anas platyrhynchos
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.85 liver
-
 Anas platyrhynchos
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Anas platyrhynchos palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.85 NADPH
-
 Anas platyrhynchos

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.85 0.00615
-
 IC50: 0.00615 mM Anas platyrhynchos avicularin
2.3.1.85 0.0456
-
 IC50: 0.0456 mM Anas platyrhynchos quercitrin
2.3.1.85 0.0746
-
 IC50: 0.0746 mM Anas platyrhynchos hyperoside
2.3.1.85 0.108
-
 IC50: 0.108 mM Anas platyrhynchos isoquercitrin