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Literature summary extracted from

  • Ciftci, M.
    Effects of some drugs on the activity of glucose 6-phosphate dehydrogenase from rainbow trout (Oncorhynchus mykiss) erythrocytes in vitro (2005), J. Enzyme Inhib. Med. Chem., 20, 485-489.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.49 marcaine noncompetitive Oncorhynchus mykiss
1.1.1.49 metamizol competitive Oncorhynchus mykiss
1.1.1.49 MgSO4 competitive Oncorhynchus mykiss
1.1.1.49 pental sodium noncompetitive Oncorhynchus mykiss
1.1.1.49 Vancomycin competitive Oncorhynchus mykiss

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + NADP+ Oncorhynchus mykiss first step in the pentose phosphate pathway D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.49 Oncorhynchus mykiss
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.49 native enzyme 2488fold from hemolysate by ammonium sulfate, dialysis, and 2',5'-ADP affinity chromatography Oncorhynchus mykiss

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.49 erythrocyte
-
 Oncorhynchus mykiss
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.49 15.43
-
 purified enzyme Oncorhynchus mykiss

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + NADP+ first step in the pentose phosphate pathway Oncorhynchus mykiss D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?
1.1.1.49 D-glucose 6-phosphate + NADP+
-
 Oncorhynchus mykiss D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.49 D-glucose 6-phosphate: NADP+ oxidoreductase
-
 Oncorhynchus mykiss
1.1.1.49 G6PD
-
 Oncorhynchus mykiss
1.1.1.49 glucose 6-phosphate dehydrogenase
-
 Oncorhynchus mykiss

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.49 NADP+
-
 Oncorhynchus mykiss

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.49 0.0446
-
 marcaine
-
 Oncorhynchus mykiss
1.1.1.49 0.392
-
 metamizol
-
 Oncorhynchus mykiss
1.1.1.49 0.748
-
 pental sodium
-
 Oncorhynchus mykiss
1.1.1.49 1.466
-
 Vancomycin
-
 Oncorhynchus mykiss
1.1.1.49 12.12
-
 MgSO4
-
 Oncorhynchus mykiss