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Literature summary extracted from
- Effects of some drugs on the activity of glucose 6-phosphate dehydrogenase from rainbow trout (Oncorhynchus mykiss) erythrocytes in vitro (2005), J. Enzyme Inhib. Med. Chem., 20, 485-489.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.49 | marcaine | noncompetitive | Oncorhynchus mykiss |  |
| 1.1.1.49 | metamizol | competitive | Oncorhynchus mykiss | |
| 1.1.1.49 | MgSO4 | competitive | Oncorhynchus mykiss | |
| 1.1.1.49 | pental sodium | noncompetitive | Oncorhynchus mykiss | |
| 1.1.1.49 | Vancomycin | competitive | Oncorhynchus mykiss | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.49 | D-glucose 6-phosphate + NADP+ | Oncorhynchus mykiss | first step in the pentose phosphate pathway | D-glucono-1,5-lactone 6-phosphate + NADPH + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.49 | Oncorhynchus mykiss | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.49 | native enzyme 2488fold from hemolysate by ammonium sulfate, dialysis, and 2',5'-ADP affinity chromatography | Oncorhynchus mykiss |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.49 | erythrocyte | - |
Oncorhynchus mykiss | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.49 | 15.43 | - |
purified enzyme | Oncorhynchus mykiss |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.49 | D-glucose 6-phosphate + NADP+ | - |
Oncorhynchus mykiss | D-glucono-1,5-lactone 6-phosphate + NADPH + H+ | - |
? | |
| 1.1.1.49 | D-glucose 6-phosphate + NADP+ | first step in the pentose phosphate pathway | Oncorhynchus mykiss | D-glucono-1,5-lactone 6-phosphate + NADPH + H+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.49 | D-glucose 6-phosphate: NADP+ oxidoreductase | - |
Oncorhynchus mykiss |
| 1.1.1.49 | G6PD | - |
Oncorhynchus mykiss |
| 1.1.1.49 | glucose 6-phosphate dehydrogenase | - |
Oncorhynchus mykiss |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.49 | NADP+ | - |
Oncorhynchus mykiss | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.49 | 0.0446 | - |
marcaine | - |
Oncorhynchus mykiss | |
| 1.1.1.49 | 0.392 | - |
metamizol | - |
Oncorhynchus mykiss | |
| 1.1.1.49 | 0.748 | - |
pental sodium | - |
Oncorhynchus mykiss | |
| 1.1.1.49 | 1.466 | - |
Vancomycin | - |
Oncorhynchus mykiss | |
| 1.1.1.49 | 12.12 | - |
MgSO4 | - |
Oncorhynchus mykiss | |
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