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Literature summary extracted from

  • Seguchi, O.; Takashima, S.; Yamazaki, S.; Asakura, M.; Asano, Y.; Shintani, Y.; Wakeno, M.; Minamino, T.; Kondo, H.; Furukawa, H.; Nakamaru, K.; Naito, A.; Takahashi, T.; Ohtsuka, T.; Kawakami, K.; Isomura, T.; Kitamura, S.; Tomoike, H.; Mochizuki, N.; Kitakaze, M.
    A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart (2007), J. Clin. Invest., 117, 2812-2824.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.18 genes MYLK2 and MYLK3, DNA and amino acid sequence determination and analysis, expression analysis in heart Danio rerio
2.7.11.18 genes MYLK2 and MYLK3, DNA and amino acid sequence determination and analysis, expression analysis in heart, sequence comparisons Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.18 additional information knockdown of cardiac-MLCK by specific siRNAs decreases cardiac-MLCK phosphorylation and impairs epinephrine-induced activation of sarcomere reassembly, knockdown of z–cardiac-MLCK expression using morpholino antisense oligonucleotides results in dilated cardiac ventricles and immature sarcomere structures Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Mg2+
-
 Homo sapiens
2.7.11.18 Mg2+
-
 Danio rerio

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + light chain myosin II Homo sapiens
-
 ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 ATP + light chain myosin II Danio rerio cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 additional information Homo sapiens ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Danio rerio
-
 cardiac/ventricular isozyme cardiac-MLCK encoded by gene MLCK3, and smooth muscle isozyme encoded by gene MLCK2
-
2.7.11.18 Homo sapiens
-
 cardiac/ventricular isozyme cardiac-MLCK encoded by gene MLCK3, and smooth muscle isozyme encoded by gene MLCK2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 embryo
-
 Danio rerio
-
2.7.11.18 heart specific cardiac/ventricular isozyme cardiac-MLCK Danio rerio
-
2.7.11.18 heart specific cardiac/ventricular isozyme cardiac-MLCK encoded by gene MLCK3, expression analysis in healthy hearts and hearts from patients with heart failure Homo sapiens
-
2.7.11.18 additional information tissue distribution analysis, overview Homo sapiens
-
2.7.11.18 myocardium
-
 Homo sapiens
-
2.7.11.18 smooth muscle specific smooth muscle isozyme smMLCK encoded by gene MLCK2 Homo sapiens
-
2.7.11.18 smooth muscle specific smooth muscle isozyme smMLCK encoded by gene MLCK2 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + light chain myosin II
-
 Homo sapiens ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 ATP + light chain myosin II cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos Danio rerio ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 ATP + light chain myosin II the cardiac-specific substrate cardiac-MLCKis phosphorylated by the cardiac-specific isozyme MLC2v Danio rerio ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 ATP + light chain myosin II the cardiac-specific substrate MLC2v is phosphorylated by the cardiac-specific isozyme cardiac-MLCK Homo sapiens ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 additional information ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 cardiac-MLCK
-
 Homo sapiens
2.7.11.18 cardiac-MLCK
-
 Danio rerio
2.7.11.18 MLCK
-
 Homo sapiens
2.7.11.18 MLCK
-
 Danio rerio
2.7.11.18 myosin light chain kinase
-
 Homo sapiens
2.7.11.18 myosin light chain kinase
-
 Danio rerio

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Homo sapiens
2.7.11.18 ATP
-
 Danio rerio