Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wagner, S.; Dybkova, N.; Rasenack, E.C.; Jacobshagen, C.; Fabritz, L.; Kirchhof, P.; Maier, S.K.; Zhang, T.; Hasenfuss, G.; Brown, J.H.; Bers, D.M.; Maier, L.S.
    Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels (2006), J. Clin. Invest., 116, 3127-3138.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 transient and stable overexpression of isozyme CaMKIIdelta in rabbit and mouse ventricular myocytes leading to a Ca2+-depdnent shift in voltage dependence of Na+ channel availability, enhanced intermediate inactivation, and slowed recovery from inactivation Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 additional information transgenic CaMKIIdelta overexpression prolongs QRS duration and repolarization, i.e. QT intervals, decreases effective refractory periods, and increases the propensity to develop ventricular tachyarrhythmia, overview, CaMKIIdelta enhances steady-state inactivation of transgenic rabbit myocyte sodium current INa, steady-state inactivation, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN93 reversible inhibition of CaMKII Mus musculus
2.7.11.17 peptide AIP i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a reversible CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cytosol isozyme CaMKIIdelta Mus musculus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Mus musculus
2.7.11.17 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + Na+-channel Mus musculus isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview ADP + phosphorylated Na+-channel
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 heart
-
 Mus musculus
-
2.7.11.17 myocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + Na+-channel
-
 Mus musculus ADP + phosphorylated Na+-channel
-
 ?
2.7.11.17 ATP + Na+-channel isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview Mus musculus ADP + phosphorylated Na+-channel
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase
-
 Mus musculus
2.7.11.17 CaMKII
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Mus musculus