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Literature summary extracted from

  • Lee, M.D.; She, Y.; Soskis, M.J.; Borella, C.P.; Gardner, J.R.; Hayes, P.A.; Dy, B.M.; Heaney, M.L.; Philips, M.R.; Bornmann, W.G.; Sirotnak, F.M.; Scheinberg, D.A.
    Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics (2004), J. Clin. Invest., 114, 1107-1116.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.88 actinonin IC50: 0.000043 mM Homo sapiens
3.5.1.88 siRNA HsPDF 581-601 transfection of HeLa cells Homo sapiens
3.5.1.88 siRNA HsPDF 659-679 transfection of HeLa cells Homo sapiens
3.5.1.88 SKI-AC-1 IC50: 0.000072 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-10 IC50: 0.000078 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11101 IC50: 0.000076 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-111101 IC50: 0.0000600 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-111110 IC50: 0.000427 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-111111 IC50: 0.000069 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-111112 IC50: 0.000234 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-111113 IC50: 0.000177 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-111114 IC50: 0.000300 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11112 IC50: 0.000365 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11113 IC50: 0.000500 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11114 IC50: 0.000276 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11115 IC50: 0.000473 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11116 IC50: 0.000335 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11117 IC50: 0.000086 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11118 IC50: 0.000115 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11119 IC50: 0.000134 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11128 IC50: 0.000522 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11138 IC50: 0.000500 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11148 IC50: 0.0000600 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11158 IC50: 0.000500 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11168 IC50: 0.000192 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11178 IC50: 0.000200 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11188 IC50: 0.000120 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-11198 IC50: 0.000090 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-3 IC50: 0.000500 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-5 IC50: 0.000400 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-51121 IC50: 0.000400 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-6 IC50: 0.000097 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-8 IC50: 0.000093 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-9 IC50: 0.000151 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-I-18 IC50: 0.000404 mM, actionin analog Homo sapiens
3.5.1.88 SKI-AC-I-19 IC50: 0.000239 mM, actionin analog Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.88 0.45
-
 formyl-Met-Thr-Met-His
-
 Homo sapiens
3.5.1.88 1.7
-
 formyl-Met-Ala-His-Ala
-
 Homo sapiens
3.5.1.88 11
-
 formyl-Met-Ala-Ser
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.88 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.88 formyl-L-methionyl peptide + H2O Homo sapiens
-
 formate + methionyl peptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.88 Homo sapiens Q9HBH1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.88 A-2780 cell
-
 Homo sapiens
-
3.5.1.88 CWR22Rv1 cell
-
 Homo sapiens
-
3.5.1.88 DAUDI cell
-
 Homo sapiens
-
3.5.1.88 DU-145 cell
-
 Homo sapiens
-
3.5.1.88 HEK-293 cell
-
 Homo sapiens
-
3.5.1.88 HeLa cell
-
 Homo sapiens
-
3.5.1.88 HL60 cell
-
 Homo sapiens
-
3.5.1.88 HT-1080 cell
-
 Homo sapiens
-
3.5.1.88 MDA-MB-468 cell
-
 Homo sapiens
-
3.5.1.88 NB-4 cell
-
 Homo sapiens
-
3.5.1.88 PBMC
-
 Homo sapiens
-
3.5.1.88 PC3 cell
-
 Homo sapiens
-
3.5.1.88 RAJI cell
-
 Homo sapiens
-
3.5.1.88 RL cell
-
 Homo sapiens
-
3.5.1.88 SK-BR-3 cell
-
 Homo sapiens
-
3.5.1.88 SK-LC-16 cell
-
 Homo sapiens
-
3.5.1.88 SK-LC-8 cell
-
 Homo sapiens
-
3.5.1.88 Tsu-Pr1 cell
-
 Homo sapiens
-
3.5.1.88 WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.88 formyl-L-methionyl peptide + H2O
-
 Homo sapiens formate + methionyl peptide
-
 ?
3.5.1.88 formyl-Met-Ala-His-Ala + H2O fMAHA Homo sapiens formate + methionyl-Ala-His-Ala
-
 ?
3.5.1.88 formyl-Met-Ala-Ser + H2O fMAS Homo sapiens formate + Met-Ala-Ser
-
 ?
3.5.1.88 formyl-Met-Thr-Met-His + H2O fMTMH Homo sapiens formate + methionyl-Thr-Met-His
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.88 HsPDF
-
 Homo sapiens
3.5.1.88 PDF
-
 Homo sapiens
3.5.1.88 peptide deformylase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.88 25
-
 activity assay Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.88 7.4
-
 activity assay Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.88 0.000043
-
 IC50: 0.000043 mM Homo sapiens GLLI
3.5.1.88 0.00006
-
 IC50: 0.0000600 mM, actionin analog Homo sapiens SKI-AC-111101
3.5.1.88 0.00006
-
 IC50: 0.0000600 mM, actionin analog Homo sapiens SKI-AC-11148
3.5.1.88 0.000069
-
 IC50: 0.000069 mM, actionin analog Homo sapiens SKI-AC-111111
3.5.1.88 0.000072
-
 IC50: 0.000072 mM, actionin analog Homo sapiens SKI-AC-1
3.5.1.88 0.000076
-
 IC50: 0.000076 mM, actionin analog Homo sapiens SKI-AC-11101
3.5.1.88 0.000078
-
 IC50: 0.000078 mM, actionin analog Homo sapiens SKI-AC-10
3.5.1.88 0.000086
-
 IC50: 0.000086 mM, actionin analog Homo sapiens SKI-AC-11117
3.5.1.88 0.00009
-
 IC50: 0.000090 mM, actionin analog Homo sapiens SKI-AC-11198
3.5.1.88 0.000093
-
 IC50: 0.000093 mM, actionin analog Homo sapiens SKI-AC-8
3.5.1.88 0.000097
-
 IC50: 0.000097 mM, actionin analog Homo sapiens SKI-AC-6
3.5.1.88 0.000115
-
 IC50: 0.000115 mM, actionin analog Homo sapiens SKI-AC-11118
3.5.1.88 0.00012
-
 IC50: 0.000120 mM, actionin analog Homo sapiens SKI-AC-11188
3.5.1.88 0.000134
-
 IC50: 0.000134 mM, actionin analog Homo sapiens SKI-AC-11119
3.5.1.88 0.000151
-
 IC50: 0.000151 mM, actionin analog Homo sapiens SKI-AC-9
3.5.1.88 0.000177
-
 IC50: 0.000177 mM, actionin analog Homo sapiens SKI-AC-111113
3.5.1.88 0.000192
-
 IC50: 0.000192 mM, actionin analog Homo sapiens SKI-AC-11168
3.5.1.88 0.0002
-
 IC50: 0.000200 mM, actionin analog Homo sapiens SKI-AC-11178
3.5.1.88 0.000234
-
 IC50: 0.000234 mM, actionin analog Homo sapiens SKI-AC-111112
3.5.1.88 0.000239
-
 IC50: 0.000239 mM, actionin analog Homo sapiens SKI-AC-I-19
3.5.1.88 0.000276
-
 IC50: 0.000276 mM, actionin analog Homo sapiens SKI-AC-11114
3.5.1.88 0.0003
-
 IC50: 0.000300 mM, actionin analog Homo sapiens SKI-AC-111114
3.5.1.88 0.000335
-
 IC50: 0.000335 mM, actionin analog Homo sapiens SKI-AC-11116
3.5.1.88 0.000365
-
 IC50: 0.000365 mM, actionin analog Homo sapiens SKI-AC-11112
3.5.1.88 0.0004
-
 IC50: 0.000400 mM, actionin analog Homo sapiens SKI-AC-5
3.5.1.88 0.0004
-
 IC50: 0.000400 mM, actionin analog Homo sapiens SKI-AC-51121
3.5.1.88 0.000404
-
 IC50: 0.000404 mM, actionin analog Homo sapiens SKI-AC-I-18
3.5.1.88 0.000427
-
 IC50: 0.000427 mM, actionin analog Homo sapiens SKI-AC-111110
3.5.1.88 0.000473
-
 IC50: 0.000473 mM, actionin analog Homo sapiens SKI-AC-11115
3.5.1.88 0.0005
-
 IC50: 0.000500 mM, actionin analog Homo sapiens SKI-AC-3
3.5.1.88 0.0005
-
 IC50: 0.000500 mM, actionin analog Homo sapiens SKI-AC-11113
3.5.1.88 0.0005
-
 IC50: 0.000500 mM, actionin analog Homo sapiens SKI-AC-11138
3.5.1.88 0.0005
-
 IC50: 0.000500 mM, actionin analog Homo sapiens SKI-AC-11158
3.5.1.88 0.000522
-
 IC50: 0.000522 mM, actionin analog Homo sapiens SKI-AC-11128