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Literature summary extracted from

  • Ganapathipillai, S.; Laval, G.; Hoffmann, I.S.; Castejon, A.M.; Nicod, J.; Dick, B.; Frey, F.J.; Frey, B.M.; Cubeddu, L.X.; Ferrari, P.
    CYP11B2-CYP11B1 haplotypes associated with decreased 11beta-hydroxylase activity (2005), J. Clin. Endocrinol. Metab., 90, 1220-1225.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.4 gene CYP11B1, DNA and amino acid sequence determination and analysis, localization on chromosome 8 adjacent to gene CYP11B2, genotyping of CwtCG and TconvGTA haplotypes Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.15.4 additional information CYP11B2-CYP11B1 haplotypes associate with decreased 11beta-hydroxylase activity, CwtCG and TconvGTA haplotype genotyping, phenotypes, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.4 11-deoxycortisol + reduced adrenal ferredoxin + O2 Homo sapiens
-
 cortisol + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 Homo sapiens
-
 aldosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 additional information Homo sapiens CYP11B2-CYP11B1 haplotypes associate with decreased 11beta-hydroxylase activity, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.4 adrenal gland
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.15.4 additional information
-
 urinary steroid profiling of halpotype mutants Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.4 11-deoxycortisol + NADPH + O2
-
 Homo sapiens cortisol + NADP+ + H2O
-
 ?
1.14.15.4 11-deoxycortisol + reduced adrenal ferredoxin + O2
-
 Homo sapiens cortisol + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
 Homo sapiens aldosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 additional information CYP11B2-CYP11B1 haplotypes associate with decreased 11beta-hydroxylase activity, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.4 11beta-hydroxylase
-
 Homo sapiens
1.14.15.4 Aldosterone synthase
-
 Homo sapiens
1.14.15.4 CYP11B1
-
 Homo sapiens
1.14.15.4 CYP11B2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.4 NADPH
-
 Homo sapiens
1.14.15.4 reduced adrenal ferredoxin
-
 Homo sapiens