BRENDA - Enzyme Database

Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate

Jarquin-Pardo, M.; Fitzpatrick, A.; Galiano, F.J.; First, E.A.; Davis, J.N.; J. Cell. Biochem. 100, 112-128 (2007)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.68
additional information
not affected by 1-butanol
Mus musculus
2.7.1.68
phosphatidic acid
0.14 mM, potent activator, the enzyme is unable to produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate unless phosphatidic acid is bound
Mus musculus
2.7.1.68
Triton X-100
optimal phosphatidic acid-stimulation of type I PIP5K activity occurs in the presence of Triton X-100
Mus musculus
Cloned(Commentary)
EC Number
Commentary
Organism
2.7.1.68
expressed in Escherichia coli
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.68
membrane
-
Mus musculus
16020
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.68
Mus musculus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.7.1.68
glutathione-Sepharose chromatography
Mus musculus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.68
fibroblast
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.68
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
675019
Mus musculus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
2.7.1.68
ATP + dipalmitoyl phosphatidylinositol 4-phosphate
-
675019
Mus musculus
ADP + dipalmitoylphosphatidylinositol 4,5-bisphosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.68
ATP
-
Mus musculus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.68
additional information
not affected by 1-butanol
Mus musculus
2.7.1.68
phosphatidic acid
0.14 mM, potent activator, the enzyme is unable to produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate unless phosphatidic acid is bound
Mus musculus
2.7.1.68
Triton X-100
optimal phosphatidic acid-stimulation of type I PIP5K activity occurs in the presence of Triton X-100
Mus musculus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.1.68
expressed in Escherichia coli
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.68
ATP
-
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.68
membrane
-
Mus musculus
16020
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.1.68
glutathione-Sepharose chromatography
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.68
fibroblast
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.68
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
675019
Mus musculus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
2.7.1.68
ATP + dipalmitoyl phosphatidylinositol 4-phosphate
-
675019
Mus musculus
ADP + dipalmitoylphosphatidylinositol 4,5-bisphosphate
-
-
-
?