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Literature summary extracted from

  • Jarquin-Pardo, M.; Fitzpatrick, A.; Galiano, F.J.; First, E.A.; Davis, J.N.
    Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate (2007), J. Cell. Biochem., 100, 112-128.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.68 additional information not affected by 1-butanol Mus musculus
2.7.1.68 phosphatidic acid 0.14 mM, potent activator, the enzyme is unable to produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate unless phosphatidic acid is bound Mus musculus
2.7.1.68 Triton X-100 optimal phosphatidic acid-stimulation of type I PIP5K activity occurs in the presence of Triton X-100 Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.68 expressed in Escherichia coli Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.68 membrane
-
 Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.68 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.68 glutathione-Sepharose chromatography Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.68 fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + dipalmitoyl phosphatidylinositol 4-phosphate
-
 Mus musculus ADP + dipalmitoylphosphatidylinositol 4,5-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.68 phosphatidylinositol 4-phosphate 5-kinase-Ibeta
-
 Mus musculus
2.7.1.68 PIP5K-Ib
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.68 ATP
-
 Mus musculus