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Literature summary extracted from

  • Ruotsalainen, H.; Sipilae, L.; Vapola, M.; Sormunen, R.; Salo, A.M.; Uitto, L.; Mercer, D.K.; Robins, S.P.; Risteli, M.; Aszodi, A.; Faessler, R.; Myllylae, R.
    Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes (2006), J. Cell Sci., 119, 625-635.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.66 additional information Mus musculus the reduction of the galactosylhydroxylysyl glucosyltransferase activity of LH3 disrupts the localization of type IV collagen, and thus the formation of basement membranes during mouse embryogenesis leading to lethality at embryonic day 9.5-14.5. Survival of hypomorphic embryos and the formation of the basement membrane are directly correlated with the level of galactosylhydroxylysyl glucosyltransferase activity. An LH3-knockout mouse lacks galactosylhydroxylysyl glucosyltransferase. Lysyl hydroxylase 3 is the main molecule responsible for galactosylhydroxylysyl glucosyltransferase activity. Galactosylhydroxylysyl glucosyltransferase is essential for the formation of the basement membrane ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.4 Mus musculus
-
-
-
2.4.1.66 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.4 bone
-
 Mus musculus
-
1.14.11.4 embryo
-
 Mus musculus
-
1.14.11.4 kidney
-
 Mus musculus
-
1.14.11.4 lung
-
 Mus musculus
-
1.14.11.4 skin
-
 Mus musculus
-
2.4.1.66 additional information the reduction of the galactosylhydroxylysyl glucosyltransferase activity of LH3 disrupts the localization of type IV collagen, and thus the formation of basement membranes during mouse embryogenesis leading to lethality at embryonic day 9.5-14.5. Survival of hypomorphic embryos and the formation of the basement membrane are directly correlated with the level of galactosylhydroxylysyl glucosyltransferase activity. An LH3-knockout mouse lacks galactosylhydroxylysyl glucosyltransferase. Lysyl hydroxylase 3 is the main molecule responsible for galactosylhydroxylysyl glucosyltransferase activity. Galactosylhydroxylysyl glucosyltransferase is essential for the formation of the basement membrane Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.4 collagen + 2-oxoglutarate + O2
-
 Mus musculus 5-hydroxylysyl-collagen + succinate + CO2
-
 ?
2.4.1.66 additional information the reduction of the galactosylhydroxylysyl glucosyltransferase activity of LH3 disrupts the localization of type IV collagen, and thus the formation of basement membranes during mouse embryogenesis leading to lethality at embryonic day 9.5-14.5. Survival of hypomorphic embryos and the formation of the basement membrane are directly correlated with the level of galactosylhydroxylysyl glucosyltransferase activity. An LH3-knockout mouse lacks galactosylhydroxylysyl glucosyltransferase. Lysyl hydroxylase 3 is the main molecule responsible for galactosylhydroxylysyl glucosyltransferase activity. Galactosylhydroxylysyl glucosyltransferase is essential for the formation of the basement membrane Mus musculus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.4 LH3
-
 Mus musculus
1.14.11.4 lysyl hydroxylase 3
-
 Mus musculus
2.4.1.66 galactosylhydroxylysyl glucosyltransferase
-
 Mus musculus
2.4.1.66 lysyl hydroxylase 3 (LH3) is a multifunctional enzyme possessing lysyl hydroxylase (LH), hydroxylysyl galactosyltransferase (GT) and galactosylhydroxylysyl glucosyltransferase (GGT) activities in vitro Mus musculus